Liosal 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Delta pharma ltd |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain
- clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABA B receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.
Dosage & Administration
- 5 mg 3 times daily
- preferably with or after food
- gradually increased
- max. 100 mg daily
- Children <10 years: Treatment is usually started with 2.5 mg given 4 times daily then raised according to requirement
Interaction
- Increased sedation may occur if Liosal is taken with agents acting on the central nervous system, alcohol or synthetic opiates
- Combined treatment with Liosal and antihypertensives is likely to increase the fall in blood pressure
- The concomitant administration of Liosal and tricyclic antidepressants may potentiate the pharmacological effects of Liosal resulting in pronounced muscular hypotonia
Contraindications
Baclofen is contraindicated in patients with hypersensitivity to any component of this product
Side Effects
- transient drowsiness
- daytime sedation
- dizziness
- weakness
- fatigue
- headache
- insomnia
- euphoria
- depression
- hypotension
- nausea
- constipation
- urinary frequency
- rash
- pruritus
- ankle oedema
- excessive perspiration
- weight gain
- nasal congestion
- visual disturbances
- hepatic function disorders
- paradoxical increase in spasticity
Pregnancy & Lactation
Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier. Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable effects on the infant would be expected
Precautions & Warnings
- Lower doses should be used for patients with impaired renal function or those undergoing chronic haemodialysis
- Patients with psychotic disorders, schizophrenia, depressive or manic disorders or confusional states should be treated cautiously and closely monitored
- Liosal may be used under appropriate supervision in patients with epilepsy and muscle spasticity
Overdose Effects
Gastric lavage is important in case of severe overdose
Therapeutic Class
Centrally acting Skeletal Muscle Relaxants
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children