Lirosal 10 mg (Tablet)
Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Novelta bestway pharma ltd |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain
- clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries
- cerebrovascular accidents
- neoplastic or degenerative brain disease
Pharmacology
- Inhibits monosynaptic and polysynaptic reflexes at the spinal level
- Stimulates GABA receptors
- Inhibits release of glutamate and aspartate
- Antinociceptive effect
- Produces CNS depression
Dosage & Administration
- Adult & children over 10 years: 5 mg 3 times daily
- Children <10 years: Treatment is usually started with 2.5 mg given 4 times daily then raised according to requirement
Interaction
- Increased sedation with CNS agents
- Increased risk of respiratory depression
- Increased fall in blood pressure with antihypertensives
- Potentiated effects with tricyclic antidepressants
- Reported mental confusion and hallucinations with levodopa and carbidopa
- CNS depressant effects with MAO inhibitors
- Possible synergistic effect with magnesium sulphate or other neuromuscular blocking agents
Contraindications
- Hypersensitivity to any component of the product
Side Effects
- Transient drowsiness
- Daytime sedation
- Dizziness
- Weakness
- Fatigue
- Headache
- Insomnia
- Euphoria
- Depression
- Confusion
- Nausea
- Constipation
- Dry mouth
- Anorexia
- Rash
- Pruritus
- Urinary frequency
- Enuresis
- Muscle hypotonia
- Respiratory depression
Pregnancy & Lactation
- Pregnancy category B3
- Safe use during pregnancy not established
- Crosses the placental barrier
- Excreted in breast milk in small quantities
Precautions & Warnings
- Lower doses for impaired renal function or chronic haemodialysis
- Cautious treatment for patients with psychotic disorders, schizophrenia, depressive or manic disorders
- Caution in patients with epilepsy
- Use with caution in patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
- Monitoring of respiratory and cardiovascular function is essential
- Neurogenic disturbances affecting bladder emptying may improve
- Poor tolerance in stroke patients
- Appropriate laboratory tests for patients with hepatic diseases or diabetes mellitus
Overdose Effects
- Gastric lavage is important in case of severe overdose
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children