Maxolax 5 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Renata limited |
| Also available as |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain, clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABAB receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.
Dosage & Administration
- Adult & children over 10 years: 5 mg 3 times daily, gradually increased; max. 100 mg daily.
- Children <10 years: Treatment is usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement.
Interactions
- Increased sedation may occur if Maxolax is taken with agents acting on the central nervous system, alcohol or synthetic opiates.
- Combined treatment with Maxolax and antihypertensives is likely to increase the fall in blood pressure.
- The concomitant administration of Maxolax and tricyclic antidepressants may potentiate the pharmacological effects of Maxolax resulting in pronounced muscular hypotonia.
Contraindications
Baclofen is contraindicated in patients with hypersensitivity to any component of this product.
Side Effects
- Transient drowsiness
- Daytime sedation
- Dizziness
- Weakness
- Fatigue
- Headache
- Insomnia
- Euphoria
- Depression
- Confusion
- Nausea
- Constipation
- Dry mouth
Pregnancy & Lactation
Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier.
Precautions & Warnings
- Lower doses should be used for patients with impaired renal function or those undergoing chronic hemodialysis.
- Patients suffering from spasticity and psychotic disorders should be treated cautiously and closely monitored.
Overdose Effects
Gastric lavage is important in case of severe overdose.
Therapeutic Class
Centrally acting Skeletal Muscle Relaxants
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.