Spinofen 10 mg (Tablet)
Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)
Strip Price: ৳ 80.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Sharif pharmaceuticals ltd |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain, clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
- inhibits monosynaptic and polysynaptic reflexes
- stimulates GABA receptors
- inhibits release of glutamate and aspartate
- antinociceptive effect
- CNS depression
- acts at intraspinal sites
Dosage & Administration
- Adult & children over 10 years: 5 mg 3 times daily
- gradually increased; max. 100 mg daily
- Children <10 years: Treatment is usually started with 2.5 mg given 4 times daily then raised according to requirement
- Daily maintenance dose for different age groups
Interaction
- Increased sedation may occur if taken with CNS agents, alcohol, or synthetic opiates
- Combined treatment with antihypertensives increases fall in blood pressure
- Potentiate effects with tricyclic antidepressants
- Reports of mental confusion, hallucinations, headaches, nausea, and agitation with Parkinson's medication
- Concurrent use with MAO inhibitors may result in increased CNS depressant effects
- Caution with magnesium sulfate or other neuromuscular blocking agents
Contraindications
- hypersensitivity to any component of the product
Side Effects
- Transient drowsiness
- daytime sedation
- dizziness
- weakness
- fatigue
- Various CNS effects
- Hypotension
- Gastrointestinal effects
- Genitourinary effects
- Other adverse reactions
Pregnancy & Lactation
- Pregnancy category B3
- Safe use during pregnancy not established
- Excretion in breast milk
- Use during pregnancy when benefits outweigh hazards
- Small quantities excreted in breast milk
Precautions & Warnings
- Lower doses for impaired renal function or chronic haemodialysis
- Cautious use in patients with psychotic or mood disorders
- Caution in patients with epilepsy
- Precaution in patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal, or respiratory failure
- Monitoring of respiratory and cardiovascular function is essential
- Neurogenic disturbances affecting bladder
- Poor tolerance in stroke patients
- Appropriate laboratory tests in patients with hepatic diseases or diabetes mellitus
Overdose Effects
- Gastric lavage is important in case of severe overdose
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children