Relentus 2 mg (Tablet)
Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tizanidine hydrochloride |
| Company | Beximco pharmaceuticals ltd |
Indications
- Treatment of painful muscle spasms
- Treatment of spasticity due to neurological disorders
Pharmacology
- Centrally acting skeletal muscle relaxant
- Principal site of action in the spinal cord
- Inhibition of excitatory amino acids
- Reduction of excessive muscle tone
- Moderate central analgesic effect
Dosage & Administration
- Narrow therapeutic index
- Individualized dose adjustment
- Low starting dose of 2 mg three times daily
- Usual dose of 2 to 4 mg three times daily
- Initial daily dose not to exceed 6 mg for spasticity due to neurological disorders
- Pediatric and geriatric patient considerations
- Special considerations for renal and hepatic impairment
- Slow down-titration upon discontinuation
Interaction
- Effects of CYP1A2 inhibitors and inducers
- Contraindicated co-administration with fluvoxamine or ciprofloxacin
- Caution with drugs known to prolong QT interval
- Considerations with antihypertensives, rifampicin, cigarette smoke, alcohol, sedatives, and other alpha-2 adrenergic agonists
Contraindications
- Known hypersensitivity to tizanidine or excipients
- Severely impaired hepatic function
- Concomitant use with strong CYP1A2 inhibitors
Side Effects
- Somnolence
- Fatigue
- Dizziness
- Dry mouth
- Hypotension
- Nausea
- Gastrointestinal disorder
- Transaminase increase
- Muscular weakness
- Insomnia
- Hallucination
- Hepatitis
- Bradycardia
Pregnancy & Lactation
- Limited experience in pregnant women
- Animal data on teratogenicity and effects on gestation
- Excretion in rat milk
- Recommendations for pregnancy testing, contraception, and fertility
Precautions & Warnings
- CYP inhibitors caution
- Hypotension risk
- Withdrawal syndrome precautions
- Hepatic dysfunction monitoring
- Renal impairment considerations
- Hypersensitivity reactions monitoring
- Driving and machine usage precautions
Use in Special Populations
- Maximal mean plasma levels in renal impairment
- No specific studies in hepatic impairment
- Limited pharmacokinetic data in geriatrics
- No clinically significant gender effect
- Impact of ethnicity and race not studied
Overdose Effects
- Reports of uneventful recovery
- Symptoms of overdose including nausea, hypotension, QT(c) prolongation, and somnolence
- Recommended elimination and symptomatic treatment
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Dry storage below 30°C
- Keep out of the reach and sight of children