Sirdalud 2 mg (Tablet)
Unit Price: ৳ 11.53 (3 x 10: ৳ 345.90)
Strip Price: ৳ 115.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Tizanidine hydrochloride |
| Company | Sandoz a novartis division |
Indications
- Treatment of painful muscle spasms
- Associated with static and functional disorders of the spine
- Following surgery for herniated intervertebral disc or osteoarthritis of the hip
- Treatment of spasticity due to neurological disorders
- Multiple sclerosis
- Chronic myelopathy
- Degenerative spinal cord diseases
- Cerebrovascular accidents
- Cerebral palsy
Pharmacology
- Centrally acting skeletal muscle relaxant
- Principal site of action is the spinal cord
- Inhibits release of excitatory amino acids
- Moderate central analgesic effect
- Effective in acute painful muscle spasms
- Effective in chronic spasticity of spinal and cerebral origin
- Reduces resistance to passive movements
- Alleviates spasms and clonus
- May improve voluntary strength
Dosage & Administration
- Narrow therapeutic index
- High inter-patient variability in plasma concentrations
- Low starting dose of 2 mg three times daily
- Usual dose for relief of painful muscle spasms is 2 to 4 mg three times daily
- Usual dose for spasticity due to neurological disorders should not exceed 6 mg initially
- Pediatric patients limited experience, not recommended
- Geriatric patients limited experience, start at lowest dose and adjust carefully
- Renal impairment: start at 2 mg once daily
- Hepatic impairment: contraindicated in severe cases
- Discontinuation should be slow to avoid rebound hypertension and tachycardia
Interaction
- Concomitant administration with CYP1A2 inhibitors may increase plasma levels
- Concomitant use with fluvoxamine or ciprofloxacin is contraindicated
- Concomitant use with other CYP1A2 inhibitors not recommended
- Caution with drugs known to prolong the QT interval
- Concomitant use with antihypertensives may cause hypotension and bradycardia
- Concomitant use with rifampicin decreases tizanidine concentrations
- Decrease in tizanidine systemic exposure with cigarette smoke
- Minimize alcohol consumption during therapy
Contraindications
- Known hypersensitivity to tizanidine or excipients
- Severely impaired hepatic function
- Concomitant use with strong CYP1A2 inhibitors
Side Effects
- Somnolence
- Fatigue
- Dizziness
- Dry mouth
- Decrease in blood pressure
- Nausea
- Gastrointestinal disorder
- Transaminase increase
- Hypotension
- Bradycardia
- Muscular weakness
- Insomnia
- Hallucination
- Hepatitis
Pregnancy & Lactation
- Limited experience in pregnant women, not recommended
- Animal data shows no evidence of teratogenicity
- Small amounts excreted in rat milk
- Females of reproductive potential recommended to use effective contraception
- No impairment of fertility observed in animal studies
Precautions & Warnings
- Cautious use with CYP inhibitors
- Risk of hypotension
- Risk of withdrawal syndrome
- Monitor hepatic function
- Increased systemic exposure in renal impairment
- Risk of hypersensitivity reactions
- Caution for activities requiring alertness
Use in Special Populations
- Maximal mean plasma levels twice as high in renal impairment
- Hepatic impairment may increase systemic exposure
- Limited pharmacokinetic data in geriatrics
- No clinically significant gender effect
- Impact of ethnicity not studied
Overdose Effects
- Reports of uneventful recovery in cases of overdose
- Symptoms may include nausea, vomiting, hypotension, QT(c) prolongation, dizziness, somnolence, miosis, restlessness, respiratory distress
- Recommended treatment includes administration of activated charcoal and forced diuresis
Therapeutic Class
- Centrally acting skeletal muscle relaxants
Storage Conditions
- Store in a dry place below 30°C
- Keep out of reach of children