Tizadin 2 mg (Tablet)
Unit Price: ৳ 5.04 (5 x 10: ৳ 252.00)
Strip Price: ৳ 50.40
Medicine Details
| Category | Details |
|---|---|
| Generic | Tizanidine hydrochloride |
| Company | Aci limited |
Title
- Tizadin
Categories
- Muscle Relaxant
- Neurological Disorder Treatment
Description
- Central muscle relaxant with moderate central analgesic effect
Indications
- Treatment of painful muscle spasms associated with static and functional disorders of the spine and following surgery
- Treatment of spasticity due to neurological disorders like multiple sclerosis and cerebral palsy
Pharmacology
- Centrally acting skeletal muscle relaxant
- Inhibits the release of excitatory amino acids
- Reduces resistance to passive movements
- Alleviates spasms and clonus
Dosage and administration
- Narrow therapeutic index and high inter-patient variability
- Initial daily dose for spasticity not to exceed 6 mg
- Pediatric use not recommended
Interaction
- Increased plasma levels with CYP1A2 inhibitors
- Contraindicated with fluvoxamine or ciprofloxacin
- Caution with drugs prolonging QT interval
- Potential interactions with antihypertensives, rifampicin, alcohol, and sedatives
Contraindications
- Hypersensitivity to tizanidine or excipients
- Severely impaired hepatic function
- Contraindicated with strong CYP1A2 inhibitors
Side effects
- Somnolence, dizziness, dry mouth, hypotension, nausea, muscular weakness, fatigue, increased transaminases
- Potential for insomnia, bradycardia, gastrointestinal disorder, and hallucinations
Pregnancy and lactation
- Limited experience in pregnant women
- Not recommended during breastfeeding
- Females of reproductive potential recommended to use effective contraception
Precautions and warnings
- Caution with CYP inhibitors and drugs prolonging QT interval
- Risk of hypotension and withdrawal syndrome
- Monitoring of liver function tests in higher doses
- Observation for hypersensitivity reactions in initial doses
- Caution with activities requiring alertness
Use in special populations
- Renal impairment increases plasma levels
- Contraindicated in severe hepatic impairment
- Limited pharmacokinetic data in geriatrics
Overdose effects
- Recovery generally uneventful
- Symptoms include nausea, vomiting, hypotension, QT(c) prolongation, somnolence, and coma
Therapeutic class
- Centrally acting Skeletal Muscle Relaxants
Storage conditions
- Store in a dry place below 30°C
- Keep out of reach and sight of children