Frenvas 10 mg (Tablet)
Unit Price: ৳ 12.04 (2 x 14: ৳ 337.12)
Strip Price: ৳ 168.56
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Radiant pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet to reduce elevated total cholesterol levels
- Reduce LDL cholesterol in patients with hypercholesterolaemia
- Reduce triglycerides levels in patients with dyslipidemia
- Reduce cardiac ischaemic events in patients with coronary artery disease
- Reduce cholesterol levels in patients with diabetes mellitus
- Reduce cholesterol levels in patients with renal transplantation
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases hepatic LDL receptors for enhanced uptake of LDL
- Rapidly absorbed after oral administration
- Metabolized to ortho- and parahydroxylated derivatives
Dosage & Administration
- Recommended starting dose of 10 or 20 mg once daily
- Dose adjustment based on lipid levels analysis
- Maximum dose of 80 mg once daily
- Can be taken with or without food
- Adjustments should be made at intervals of 4 weeks or more
Interactions
- Increased risk of myopathy with cyclosporine
- Plasma concentrations decreased with antacid coadministration
- Plasma concentrations decreased with colestipol coadministration
- Steady-state plasma digoxin concentrations increased with digoxin coadministration
- Plasma concentrations increased with erythromycin coadministration
- AUC values increased with oral contraceptive coadministration
Contraindications
- Hypersensitivity to any component of the medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Rash
- Myalgia
Pregnancy & Lactation
- Contraindicated during pregnancy
- Not recommended during breastfeeding
- No controlled clinical trials in pregnant women
- Animal studies show toxicity to reproduction
- Potential reduction in fetal levels of mevalonate
Precautions & Warnings
- Liver function tests should be performed before initiation of treatment
- Discontinue therapy if markedly elevated CPK levels occur
- Use with caution in patients with substantial alcohol consumption
- Use with caution in patients with history of liver disease
Use in Special Populations
- Higher plasma concentrations in healthy elderly subjects
- No significant difference in LDL-C reduction between men and women
- Renal disease does not influence plasma concentrations
- Clinical data suggest greater LDL-lowering in elderly patients
Overdose Effects
- Specific treatment not available
- Symptomatic treatment and supportive measures
- Liver function tests should be performed
- Serum CK levels should be monitored
- Hemodialysis not expected to significantly enhance clearance
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
- Keep in dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
Common Questions about Frenvas 10 mg Tablet
- Used to avoid heart attacks and treat hypercholesterolemia
- Should be taken orally, once daily at the same time
- Treating conditions like Mixed Dyslipidemia and Hypertriglyceridemia
- Possible side effects include cough, muscle pain, and breathing difficulty
- Storage at room temperature away from heat and light
- Classified as statins to lower cholesterol and prevent heart attack risk