Dyzin 5 mg/5 ml (Syrup)
60 ml bottle: ৳ 22.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cetirizine hydrochloride |
| Company | Amico laboratories ltd |
| Also available as |
Indications
- Relief of symptoms associated with seasonal & perennial allergic rhinitis
- Treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria
- Treatment of allergen-induced asthma
Pharmacology
- Potent H1 receptor antagonist
- No significant anticholinergic and antiserotonic effects
- Inhibits histamine-mediated early phase of allergic reaction
- Reduces migration of inflammatory cells
- Reduces release of mediators associated with late phase of allergic reaction
- Peak plasma concentration of 257 mcg/L within one hour of administration
- Plasma half-life of approximately 11 hours
- Renal clearance of 30 ml/minute
- Excretion half-life of approximately nine hours
Dosage & Administration
- Adults and Children 6 years and older: 1 tablet or 2 teaspoonfuls daily
- Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoonful twice daily
- Children 6 months to 2 years: 1/2 teaspoonful once daily
- Recommended intravenous dosage regimen for acute urticaria
- Dosage varies for different age groups
- Not recommended in pediatric patients less than 6 years of age with impaired renal or hepatic function
Interaction
- No clinically significant drug interactions with Theophylline, Azithromycin, Pseudoephedrine, Ketoconazole, or Erythromycin
Contraindications
- History of hypersensitivity to Cetirizine or hydroxyzine
Side Effects
- Most common side effect is somnolence
Pregnancy & Lactation
- US FDA Pregnancy Category B
- No adequate and well-controlled studies in pregnant women
- Excreted in human milk
- Caution advised during pregnancy and lactation
Precautions & Warnings
- Caution advised when driving a car or operating heavy machinery
Use in Special Populations
- Total body clearance reduced and AUC and half-life increased in mild to moderate hepatic and renal impairment
- Safety demonstrated in pediatric patients aged 6 months to 5 years
- Clearance reduced in elderly patients in proportion to decreased creatinine clearance
Therapeutic Class
- Sedating Anti-histamine
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children