Trizin 5 mg/5 ml (Syrup)
60 ml bottle: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cetirizine hydrochloride |
| Company | Navana pharmaceuticals ltd |
| Also available as |
Indications
- Relief of symptoms associated with seasonal & perennial allergic rhinitis
- Treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria
- Treatment of allergen induced asthma
Pharmacology
- Potent H1 receptor antagonist
- No significant anticholinergic and antiserotonic effects
- Inhibits histamine-mediated early phase of allergic reaction
- Reduces migration of inflammatory cells
- Reduces release of mediators associated with late phase of allergic reaction
- Peak plasma concentrations of 257 mcg/L within one hour of administration (980 mcg/L in children)
- Plasma half-life is approximately 11 hours
Dosage & Administration
- Adults and Children 6 years and older: 1 tablet or 2 teaspoonfuls daily (or 1 teaspoonful twice daily)
- Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoonful twice daily
- Children 6 months to 2 years : 1/2 teaspoonful once daily
- Recommended dosage regimen for Cetirizine injectable dosage form
- Not recommended in pediatric patients less than 6 years of age with impaired renal or hepatic function
Interaction
- No clinically significant drug interactions with Theophylline, Azithromycin, Pseudoephedrine, Ketoconazole, or Erythromycin
Contraindications
- Contraindicated in patients with a history of hypersensitivity to Cetirizine or hydroxyzine
Side Effects
- Most common side effect is somnolence
Pregnancy & Lactation
- US FDA Pregnancy Category: B
- Use during pregnancy only if clearly needed
- Caution should be exercised when administered to a nursing woman
Precautions & Warnings
- Caution should be exercised when driving a car or operating heavy machinery
Use in Special Populations
- In patients with mild to moderate hepatic and renal impairment, total body clearance of Trizin is reduced and AUC and half-life increased by about 2 to 3 fold
- Safety demonstrated in pediatric patients aged 6 months to 5 years
- Clearance of Trizin is reduced in elderly patients, but only in proportion to the decrease in creatinine clearance
Therapeutic Class
- Sedating Anti-histamine
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children