Axodin 30 mg/5 ml (Oral Suspension)

50 ml bottle: ৳ 55.00

Medicine Details

Category Details
Generic Fexofenadine hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Axodin 60 mg tablet Axodin 120 mg tablet Axodin 180 mg tablet

Chemical structure

  • Molecular Formula: C32H39NO4

Therapeutic class

  • Non-sedating antihistamines

Storage conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Dosage and administration

  • Adults and children 12 years and older:
  • Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
  • In case of impaired renal function: 60 mg once daily
  • Children from 6 to 11 years:
  • Tablet: 30 mg twice daily or 60 mg once daily
  • In case of impaired renal function: 30 mg once daily
  • Children from 2 to 11 years:
  • Suspension: 30 mg or 5 ml twice daily
  • In case of impaired renal function: 30 mg or 5 ml once daily
  • Children from 6 months to less than 2 years:
  • Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily
  • In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily

Interactions

  • Coadministration of Axodin with erythromycin or ketoconazole results in a 2-3 times increase in the level of fexofenadine in plasma
  • No interaction between fexofenadine and omeprazole was observed
  • Administering an antacid containing aluminium and magnesium hydroxide gels 15 minutes prior to Axodin causes a reduction in bioavailability

Contraindications

  • Contraindicated in patients with known hypersensitivity to Fexofenadine Hydrochloride or any of its ingredients

Side effects

  • Headache
  • Drowsiness
  • Dizziness
  • Nausea
  • Fatigue
  • Hypersensitivity reactions with manifestations such as angioedema, chest tightness, dyspnoea, flushing, and systemic anaphylaxis
  • Insomnia
  • Nervousness
  • Sleep disorders
  • Tachycardia
  • Palpitations
  • Diarrhea
  • Rash
  • Urticaria
  • Pruritus

Pregnancy and lactation

  • Not recommended for use during pregnancy unless clearly necessary
  • Not recommended for mothers breast-feeding their babies

Precautions and warnings

  • Administered with care in older people and renally or hepatically impaired patients
  • Patients with a history of or ongoing cardiovascular disease should be warned of the potential adverse reactions

Special populations

  • The pharmacokinetics of fexofenadine are altered in individuals with renal impairment
  • Moderate to severe hepatic disease does not affect the pharmacokinetics of fexofenadine substantially
  • Adverse events were similar in elderly patients compared to those under 65 years of age
  • Increased bioavailability in individuals over 65 years of age

Overdose effects

  • Dizziness
  • Drowsiness
  • Fatigue
  • Dry mouth
  • Single doses up to 800 mg and doses up to 690 mg twice daily for 1 month or 240 mg once daily for 1 year have been administered to healthy subjects without the development of clinically significant adverse reactions
  • Maximum tolerated dose has not been established
  • Haemodialysis does not effectively remove Axodin from blood

Indications

  • Relief of symptoms associated with seasonal and perennial allergic rhinitis in adults and children 12 years of age and over
  • Relief of symptoms associated with chronic idiopathic urticaria in adults and children 12 years of age and over

Pharmacology

  • Fexofenadine is considered an "inverse agonist" of the H1 receptor
  • Has a potent and selective affinity for H1 receptors
  • Does not carry antidopaminergic, antiserotonergic, anticholinergic, sedative, or adrenergic blocking activity
  • Does not cross the blood-brain barrier

Use cases

    • Allergic Rhinitis: Relief of symptoms including sneezing, rhinorrhea, lacrimation, itchy, red eyes, and itchy nose/palate/throat
    • Chronic Idiopathic Urticaria: Relief of symptoms including signs and symptoms of chronic idiopathic urticaria, the number of wheals, and pruritus

Interaction details

  • Erythromycin or ketoconazole coadministration: 2-3 times increase in fexofenadine level in plasma
  • No interaction with omeprazole
  • Antacid containing aluminium and magnesium hydroxide gels: Reduces bioavailability

Side effects details

  • Headache
  • Drowsiness
  • Dizziness
  • Nausea
  • Fatigue
  • Hypersensitivity reactions (e.g., angioedema, chest tightness, dyspnoea, flushing, systemic anaphylaxis)
  • Insomnia
  • Nervousness
  • Sleep disorders or nightmares/excessive dreaming (paroniria)
  • Tachycardia
  • Palpitations
  • Diarrhea
  • Rash
  • Urticaria
  • Pruritus

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