Lipostat 20 mg (Tablet)

Product Title

• Lipostat 20 mg Tablet

Category

• Medicine
• Pharmaceuticals
• Cholesterol Management

Dosage Form

• Tablet

Dosage Strength

• 20 mg

Active Ingredient

• Atorvastatin

Therapeutic Class

• Other Anti-anginal & Anti-ischaemic drugs
• Statins

Indications

• Reduction of total cholesterol levels
• Reduction of LDL cholesterol levels
• Reduction of apolipoprotein B levels
• Reduction of triglycerides levels
• Heterozygous familial hypercholesterolaemia
• Homozygous familial hypercholesterolaemia
• Mixed dyslipidemia (Fredrickson Type Ia and Ib)
• Hypertriglyceridaemia (Fredrickson Type IV)
• Dysbetalipoproteinaemia (Fredrickson Type III)
• Asymptomatic or mild to moderate symptomatic coronary artery disease
• Hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation

Mode of Action

• Inhibition of HMG-CoA reductase
• Lowering plasma cholesterol and lipoprotein levels
• Enhanced uptake and catabolism of LDL

Absorption

• Rapid absorption after oral administration
• Maximum plasma concentrations within 1 to 2 hours

Distribution

• Mean volume of distribution approximately 381 liters
• 98% bound to plasma proteins

Metabolism

• Extensive metabolism to ortho- and parahydroxylated derivatives and beta-oxidation products
• Importance of metabolism by cytochrome P450 3A4

Excretion

• Elimination primarily in bile
• Plasma elimination half-life approximately 14 hours

Interaction

• Increased myopathy risk with concurrent administration of certain drugs
• Changes in plasma concentrations when coadministered with antacids, colestipol, digoxin, erythromycin, oral contraceptives, or warfarin

Contraindications

• Hypersensitivity to any component of the medication
• Active liver disease
• Unexplained persistent elevations of serum transaminases
• History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

• Constipation
• Flatulence
• Dyspepsia
• Abdominal pain
• Infection
• Headache
• Back pain
• Rash
• Asthenia
• Arthralgia
• Myalgia

Pregnancy & Lactation

• Contraindicated during pregnancy
• Not recommended during breastfeeding
• Potential for serious adverse reactions
• Lack of established safety in pregnant women

Precautions & Warnings

• Liver function tests before initiation and periodically thereafter
• Discontinuation if markedly elevated CPK levels occur or myopathy is diagnosed or suspected

Use in Special Populations

• Higher plasma concentrations in elderly subjects
• No pediatric pharmacokinetic data available
• No clinically significant gender differences
• No dose adjustment necessary for renal dysfunction

Overdose Effects

• Specific treatment not available
• Symptomatic treatment and supportive measures
• Liver function tests and serum CK level monitoring

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C33H35FN2O5
• Chemical Structure Image

Commonly Asked Questions

• Description and uses of Lipostat 20 mg Tablet
• Administration instructions
• Side effects and their possible seriousness
• Storage and disposal instructions
• Cholesterol-lowering effects and impact on diabetes risk
• Duration of use and potential side effects
• Pediatric use and blood thinning effects

Pharmacology Details

• Specific details on atorvastatin's mechanism of action
• Absorption, distribution, metabolism, and excretion details
• Interaction details with specific drugs

Dosage & Administration Details

• Specific dosage recommendations for different conditions
• Guidelines for cholesterol-lowering diet before and during treatment
• Recommended starting doses and dosage adjustments based on lipid levels
• Recommended dose range
• Administration time and food considerations
• Pediatric dosage recommendations

Interaction Details

• Specific drug interactions and their effects on atorvastatin plasma concentrations
• Details on antacid, colestipol, digoxin, erythromycin, oral contraceptives, and warfarin interactions

Precautions & Warnings Details

• Liver function test requirements
• Use caution in patients with alcohol consumption or history of liver disease
• Discontinuation criteria for markedly elevated CPK levels or myopathy diagnosis or suspicion

Use in Special Populations Details

• Pharmacokinetic differences in elderly subjects
• Absence of pediatric pharmacokinetic data
• Gender differences, if any
• Need for dose adjustment in renal dysfunction
• Impact of hemodialysis and hepatic insufficiency

Miscellaneous Information

• Reference to specific chemical structure image
• Commonly asked questions and quick tips for users

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