Xofedin 120 mg (Tablet)
Unit Price: ৳ 6.52 (30's pack: ৳ 195.60)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fexofenadine hydrochloride |
| Company | Amulet pharmaceuticals ltd |
| Also available as |
Title
- Xofedin 120 mg Tablet
Categories
- Medicine
- Non-sedating antihistamines
Description
- Xofedin is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis, in adults and children 12 years of age and over. Symptoms treated effectively include sneezing, rhinorrhea, lacrimation, itchy, red eyes and itchy nose/palate/throat.
- The H1 histamine receptor is responsible for mediating hypersensitivity and allergic reactions. Fexofenadine is considered an 'inverse agonist' of the H1 receptor because it binds to and stabilizes the inactive form of the receptor, preventing its activation and subsequent downstream effects.
- Xofedin does not undergo hepatic biotransformation and therefore will not interact with other medicinal products through hepatic mechanisms.
- Contraindicated in patients with known hypersensitivity to Fexofenadine Hydrochloride or any of its ingredients.
Dosage & Administration
- Adults and children 12 years and older: Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily. In case of impaired renal function: 60 mg once daily.
- Children from 6 to 11 years: Tablet: 30 mg twice daily or 60 mg once daily. In case of impaired renal function: 30 mg once daily.
- Children from 6 months to less than 2 years: Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily.
Pharmacology
- Fexofenadine has a potent and selective affinity for H1 receptors. It does not carry antidopaminergic, antiserotonergic, anticholinergic, sedative, or adrenergic blocking activity. Fexofenadine does not cross the blood-brain barrier and thus is unlikely to cause significant CNS effects.
Interaction
- Coadministration of Xofedin with erythromycin or ketoconazole has been found to result in a 2-3 times increase in the level of fexofenadine in plasma. No interaction between fexofenadine and omeprazole was observed. Administration of an antacid containing aluminium and magnesium hydroxide gels 15 minutes prior to Xofedin caused a reduction in bioavailability.
Contraindications
- Known hypersensitivity to Fexofenadine Hydrochloride or any of its ingredients.
Side Effects
- Common undesirable effects reported in clinical trials include headache, drowsiness, dizziness, and nausea. Post-marketing surveillance reports hypersensitivity reactions, insomnia, tachycardia, diarrhea, and rash.
Pregnancy & Lactation
- Not recommended for use during pregnancy unless clearly necessary. Fexofenadine was found to cross into human breast milk, therefore not recommended for mothers breastfeeding their babies.
Precautions & Warnings
- Limited data available for use in older people and renally or hepatically impaired patients. Patients with a history of or ongoing cardiovascular disease should be warned of potential adverse reactions.
Use in Special Populations
- Renally impaired patients: A dose of 60 mg once daily is recommended as the starting dose. Moderate to severe hepatic disease does not affect the pharmacokinetics of fexofenadine substantially.
Overdose Effects
- Reported effects of Xofedin overdose include dizziness, drowsiness, fatigue, and dry mouth. Maximum tolerated dose has not been established. Symptomatic and supportive treatment is recommended.
Therapeutic Class
- Non-sedating antihistamines
Storage Conditions
- Keep in a dry place away from light and heat. Keep out of the reach of children.
Chemical Structure
- Molecular Formula: C32H39NO4
Common Questions
- What is Xofedin 120 mg Tablet? It is an antihistamine that blocks histamine during allergic reactions.
- What are the uses of Xofedin 120 mg Tablet? Treatment of allergic rhinitis and urticaria.
- What are the Side Effects of Xofedin 120 mg Tablet? Vomiting, Headache, Coughing, Diarrhea, Painful menstruation, Hives, redness of skin, Swelling of face, lips, eyelids, tongue, hands and feet.
Additional Information
- Fexofenadine is ineffective at crossing the blood-brain barrier, reducing the likelihood of CNS effects.
- Dosage varies based on the patient's age and renal function.
- Avoid coadministration with antacids to prevent reduced bioavailability.