Locol 10 mg (Tablet)

Unit Price: ৳ 10.04 (3 x 10: ৳ 301.20)
Strip Price: ৳ 100.40

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Popular pharmaceuticals ltd
Also available as
Locol 20 mg tablet

Title

  • Locol 10 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • Locol is indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various diseases when response to diet and other non-pharmacological measures is inadequate.

Dimensions

  • Tablet

Color Options

  • N/A

Functions

  • Reduces elevated total cholesterol
  • Lowers LDL cholesterol levels
  • Reduces apolipoprotein B levels
  • Lowers triglycerides levels
  • Inhibits HMG-CoA reductase
  • Increases hepatic LDL receptors

Materials

  • Atorvastatin

Technical Specifications

  • Molecular Formula: C33H35FN2O5

Design Elements

  • Selective inhibitor of HMG-CoA reductase
  • Chemical Structure with Molecular Formula

Usability Features

  • Treatment for familial hypercholesterolaemia
  • Helps in the prevention of cardiovascular events
  • Used to avoid heart attacks
  • Treatment for mixed dyslipidemia and hypertriglyceridemia
  • Adjunct to diet to reduce elevated cholesterol and triglycerides levels

Indications

  • Reduction of total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
  • Reduction of elevated cholesterol and triglycerides in patients with mixed dyslipidemia (Fredrickson Type Ia and Ib)
  • Treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia (Fredrickson Type IV)
  • Treatment of patients with dysbetalipoproteinaemia (Fredrickson Type III)
  • Reduction of cardiac ischemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease with elevated LDL-cholesterol level
  • Reduction of total and LDL-cholesterol concentrations in patients with hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation

Pharmacology

  • Selective inhibitor of HMG-CoA reductase
  • Lowers plasma cholesterol and lipoprotein levels
  • Rapid absorption after oral administration
  • Extensively metabolized to ortho- and parahydroxylated derivatives
  • Eliminated primarily in bile
  • Plasma elimination half-life approximately 14 hours

Dosage & Administration

  • Adults: Usually 10 mg once daily; may be increased to max. 80 mg once daily if necessary
  • Children (10-18 years): Initially 10 mg once daily, increased if necessary to max. 20 mg once daily

Interactions

  • Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
  • Decreased plasma concentrations of atorvastatin when coadministered with antacid suspension or colestipol
  • Increased plasma concentrations of digoxin, erythromycin, and oral contraceptives when coadministered with atorvastatin
  • No clinically significant effect on prothrombin time when coadministered with warfarin

Contraindications

  • Hypersensitivity to any component
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy & Lactation

  • Contraindicated during pregnancy
  • Not known whether excreted in human milk

Precautions & Warnings

  • Liver function tests should be performed before initiation of treatment and periodically thereafter
  • Use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
  • Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected

Use in Special Populations

  • Plasma concentrations in healthy elderly subjects are higher than in young adults
  • No clinically significant difference in LDL-C reduction between men and women
  • Renal disease has no influence on plasma concentrations or LDL-C reduction
  • In patients with chronic alcoholic liver disease, plasma concentrations are markedly increased

Overdose Effects

  • Specific treatment not available
  • Symptomatic treatment and supportive measures instituted
  • Liver function tests and serum CK levels should be monitored

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Commonly Asked Questions

  • What is Locol 10 mg Tablet?
  • How should I take Locol 10 mg Tablet?
  • What are the uses of Locol 10 mg Tablet?
  • What are the Side Effects of Locol 10 mg Tablet?
  • What are the instructions for storage and disposal Locol 10 mg Tablet?
  • Is Locol 10 mg Tablet used for lowering cholesterol?
  • Will taking Locol 10 mg Tablet increase my risk of diabetes?
  • For how long do I need to take Locol 10 mg Tablet? Is it safe for long-term use?
  • Does Locol 10 mg Tablet cause weight loss?
  • Can I stop taking Locol 10 mg Tablet?
  • Does Locol 10 mg Tablet cause memory loss?
  • Does Locol 10 mg Tablet make you tired?
  • Can Locol 10 mg Tablet be prescribed to children?
  • Is Locol 10 mg Tablet a blood thinner?
  • Quick Tips: Locol 10 mg Tablet is safe; may cause diarrhea, gas or an upset stomach; Inform your doctor if you experience fatigue, muscle weakness or muscle pain

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