Locol 20 mg (Tablet)

Unit Price: ৳ 18.07 (2 x 10: ৳ 361.40)

Strip Price: ৳ 180.70

Medicine Details

Category	Details
Generic	Atorvastatin calcium
Company	Popular pharmaceuticals ltd
Also available as	Locol 10 mg tablet

Title

Locol 20 mg Tablet

Description

A selective inhibitor of HMG-CoA reductase used to reduce elevated levels of cholesterol and triglycerides.

Dosage and administration

Adults: 10-80 mg once daily
Children (10-18 years): 10-20 mg once daily
Initial dose for familial hypercholesterolaemia: 10 mg daily, increased to 40-80 mg once daily

Pharmacology

Mode of action: Inhibits HMG-CoA reductase to lower plasma cholesterol and lipoprotein levels
Absorption: Rapidly absorbed after oral administration; maximum plasma concentrations within 1 to 2 hours
Metabolism: Extensively metabolized to active derivatives by cytochrome P450 3A4
Excretion: Primarily eliminated in bile following hepatic and/or extra-hepatic metabolism

Indications

Reduction of total cholesterol and LDL cholesterol in familial hypercholesterolaemia
Treatment of hypertriglyceridaemia and dyslipidemia
Prevention of cardiac ischaemic events in asymptomatic or mild to moderate coronary artery disease

Contraindications

Hypersensitivity to any component of the medication
Active liver disease or unexplained persistent elevations of serum transaminases
History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side effects

Constipation
Flatulence
Dyspepsia
Abdominal pain
Headache
Rash
Myalgia
Asthenia

Pregnancy and lactation

Contraindicated during pregnancy and breastfeeding; potential for serious adverse reactions

Precautions and warnings

Liver function tests should be performed before initiation of treatment; caution in patients with substantial alcohol consumption or history of liver disease

Special populations

Geriatric: Higher plasma concentrations in elderly subjects
Pediatric: Limited pharmacokinetic data available for the pediatric population
Gender: No clinically significant difference in LDL-C reduction between men and women

Interactions

Increased risk of myopathy with concurrent administration of specific drugs
Reduced plasma concentrations when coadministered with antacid or colestipol
Potential increase in plasma concentrations of digoxin, erythromycin, oral contraceptives

Overdose effects

Specific treatment not available; monitor liver function and serum CK levels

Storage conditions

Store in a dry place away from light and heat; keep out of the reach of children

Chemical structure

Molecular formula: C33H35FN2O5
Image url: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Therapeutic class

Other Anti-anginal & Anti-ischaemic drugs
Statins