Orvatin 20 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Title
Orvatin 20 mg Tablet
Categories
- Medication
- Health
- Cardiovascular
Description
Orvatin 20 mg Tablet is a selective inhibitor of HMG-CoA reductase, indicated to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various diseases when response to diet and other non-pharmacological measures is inadequate.
Dosage
- Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to max. 80 mg once daily.
- Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 20 mg once daily.
- Doses for familial hypercholesterolaemia, prevention of cardiovascular events, and pediatric use
Pharmacology
Atorvastatin is a selective inhibitor of HMG-CoA reductase, responsible for the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. Atorvastatin lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver.
Absorption
Atorvastatin is rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours.
Metabolism
Atorvastatin is extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products.
Excretion
Atorvastatin and its metabolites are eliminated primarily in bile following hepatic and/or extra-hepatic metabolism.
Interaction
- Cyclosporine
- Fibric acid derivatives
- Niacin
- Erythromycin
- Azole antifungals
- Antacid
- Colestipol
- Digoxin
- Oral Contraceptives
- Warfarin
Contraindications
- Hypersensitivity to any component
- Active liver disease
- Unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy lactation
- Contraindicated during pregnancy
- Not known whether excreted in human milk
- Maternal treatment with atorvastatin may reduce fetal levels of mevalonate
- Atorvastatin should not be used in women who are pregnant, trying to become pregnant, or suspect they are pregnant
- Contraindicated during breastfeeding
Precautions warnings
- Liver function tests should be performed before initiation of treatment and periodically thereafter
- Orvatin should be used with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
Storage conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Chemical structure
- Molecular formula: C33H35FN2O5
- Chemical structure image: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg
Common questions
- What is Orvatin 20 mg Tablet?: A selective inhibitor of HMG-CoA reductase used to avoid heart attacks and treat conditions such as Mixed Dyslipidemia and Hypertriglyceridemia.
- How should I take Orvatin 20 mg Tablet?: Orvatin 20 mg Tablet should be taken by mouth once daily, at the same time each day, with or without food.
- What are the uses of Orvatin 20 mg Tablet?: Used for the treatment of diseases like Mixed Dyslipidemia and Hypertriglyceridemia, heart attacks, and Primary Hypercholesterolemia.
- What are the Side Effects of Orvatin 20 mg Tablet?: Possible side-effects include cough, muscle pain, breathing difficulty, and running nose.
- What are the instructions for storage and disposal Orvatin 20 mg Tablet?: Store at room temperature, away from heat and direct light. Keep out of the reach of children and pets.
- Is Orvatin 20 mg Tablet used for lowering cholesterol?: Yes, it is used to lower cholesterol and triglycerides present in the blood.
- Will taking Orvatin 20 mg Tablet increase my risk of diabetes?: It can slightly affect blood sugar levels; regular monitoring is important.
- For how long do I need to take Orvatin 20 mg Tablet? Is it safe for long-term use?: Should be taken for the prescribed duration; considered safe for long-term use if taken as directed.
- Does Orvatin 20 mg Tablet cause weight loss?: No studies report weight loss as a side effect.
- Can I stop taking Orvatin 20 mg Tablet?: Do not stop without informing your doctor; completing the course is necessary.
- Does Orvatin 20 mg Tablet cause memory loss?: Very rare side effect; consult a doctor if experienced.
- Does Orvatin 20 mg Tablet make you tired?: It can make you feel tired; exact reason unknown.
- Can Orvatin 20 mg Tablet be prescribed to children?: Should be used by adults; caution for children above 10 years of age.
Special populations
- Geriatric: Plasma concentrations of Orvatin are higher in healthy elderly subjects than in young adults.
- Pediatric: Pharmacokinetic data in the pediatric population are not available.
- Gender: No clinically significant difference in LDL-C reduction between men and women.
- Renal Insufficiency: No influence on the plasma concentrations or LDL-C reduction of Orvatin.
- Hemodialysis: Not expected to significantly enhance clearance of Orvatin.
- Hepatic Insufficiency: Plasma concentrations of Orvatin are markedly increased in patients with chronic alcoholic liver disease.
Overdose effects
Specific treatment is not available for atorvastatin overdose; treat symptomatically and monitor liver function tests and serum CK levels.
Drug classes
- Other Anti-anginal & Anti-ischaemic drugs
- Statins