Paftrol 10 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Rupatadine fumarate
Company Navana pharmaceuticals ltd
Also available as
Paftrol 5 mg oral solution

Indications

  • Symptomatic treatment of Seasonal Allergic Rhinitis
  • Symptomatic treatment of Perennial Allergic Rhinitis
  • Symptomatic treatment of Urticaria

Pharmacology

  • Long-acting non-sedative antagonist of histamine H1-receptors
  • Antagonizes platelet activating factor (PAF)
  • Better therapeutic effect than isolated antihistamine
  • Inhibition of mast cell degranulation
  • Inhibition of cytokine release

Dosage & Administration

  • Adults and adolescents (over 12 years): Recommended dose is 10 mg once a day
  • Children aged 2 to 11 years:
    • Children weighing 25 kg or more: 1 teaspoonful (5 ml) of the oral solution once daily
    • Children weighing equal or more than 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) oral solution once daily

Interaction

  • With medicine:
    • Increased systemic exposure with ketoconazole or erythromycin
    • Caution when administered with CYP3A4 inhibitors, statins, CNS depressants, or alcohol
  • With food: Grapefruit and Grapefruit juice should not be taken simultaneously

Contraindications

Hypersensitivity to Rupatadine or excipients

Side Effects

  • Asthenia
  • Drowsiness
  • Appetite increased
  • Arthralgia
  • Back pain
  • Constipation
  • Cough
  • Diarrhea
  • Dry throat
  • Epistaxis
  • Fever
  • Nausea
  • Rash
  • Vomiting
  • Palpitations
  • Tachycardia

Pregnancy & Lactation

  • Not recommended during pregnancy unless potential benefit outweighs potential risk
  • Not recommended during lactation unless benefits justify risk to the infant

Precautions & Warnings

  • Caution in patients with known prolongation of the QT interval
  • Caution in patients with uncorrected hypokalemia
  • Caution in patients with proarrhythmic conditions
  • Caution in elderly patients (65 years and older)

Use in Special Populations

  • Elderly: Use with caution
  • Children: Not established in patients less than 12 years of age
  • Patients with renal or hepatic insufficiency: Not recommended

Overdose Effects

Symptomatic treatment for accidental ingestion of very high doses

Therapeutic Class

Non-sedating antihistamines

Storage Conditions

Store below 30°C, protect from light and moisture

Chemical Structure

  • Molecular Formula: C26H26ClN3
  • Chemical Structure available

Common Questions about Paftrol 10 mg Tablet

  • What is Paftrol 10 mg Tablet?: H1-receptors antagonist, also antagonizes platelet activating factor (PAF)
  • What is Paftrol 10 mg Tablet used for?: Treatment of seasonal & perennial allergic rhinitis and urticaria
  • Pregnancy warnings: Maybe unsafe during pregnancy
  • Breast-feeding warnings: Unknown, consult your doctor
  • Effect on kidney function: Caution advised in patients with renal impairment
  • Effect on liver function: No data available, consult your doctor
  • Onset of action: Initiated within 75 minutes after administration
  • Duration of effect: 8 to 10 hours
  • Quick Tips:
    • Prescribed to relieve allergy symptoms
    • Less likely to cause sleepiness compared to other similar medications
    • May cause dizziness and sleepiness, be cautious while driving
    • Avoid alcohol consumption
    • Stop taking Rupa at least three days before an allergy test

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