Oradin Plus 10 mg+240 mg (Tablet (Extended Release))

Indications

• Relief of nasal congestion
• Relief of runny nose
• Relief of sneezing
• Relief of itchy, watery eyes
• Relief of itching of the nose or throat
• Relief of swelling of nasal passages
• Relief of sinus congestion and pressure

Pharmacology

• Non-sedative histamine H1-receptor antagonist
• Long-acting tricyclic anti-histamine
• Selective peripheral H1-receptor antagonistic activity
• Orally active sympathomimetic amine
• Decongestant action on the nasal mucosa
• Nasal and bronchial decongestant activity
• Alpha- and beta-adrenergic receptor agonist

Dosage

• Dosage for adults and children over 12 years
• Lower initial dose for patients with renal insufficiency
• Not recommended for patients with difficulty swallowing tablets

Administration

• Administered in patients 12 years of age and older

Interaction

• Contraindicated in patients taking MAO inhibitors
• May reduce antihypertensive effects of beta-adrenergic blocking agents
• May increase plasma concentration of Loratadine and Decarboethoxyloratadine when administered with Erythromycin, Ketoconazole, or Cimetidine

Contraindications

• Contraindicated in patients hypersensitive to any component of the product

Side Effects

• Common side effects like dry mouth, somnolence, insomnia, pharyngitis, dizziness, coughing, fatigue, nausea, nervousness, anorexia, dysmenorrheal, headache
• Less common side effects like increased sweating, thirst, back pain, chest pain, malaise, palpitations, hypertension, tachycardia, abdominal distension, altered taste, flatulence, myalgia, dry throat, agitation, micturation frequency

Pregnancy & Lactation

• Pregnancy category B
• Not recommended for lactating mothers

Precautions & Warnings

• Avoid in patients with hepatic insufficiency
• Used with caution in patients with hypertension, diabetes mellitus, ischemic heart disease, increased intraocular pressure, hyperthyroidism, or renal impairment
• Patients with renal insufficiency should be given a lower initial dose

Overdose Effects

• Institute general symptomatic and supportive measures in the event of overdosage
• Treatment may consist of emesis (ipecac syrup), activated charcoal administration, or gastric lavage

Therapeutic Class

• Anti-histamine & decongestant

Storage Conditions

• Store at a cool and dry place, away from light
• Keep out of the reach of children

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