TCL-R 20 mg (Tablet)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Aristopharma ltd |
| Also available as |
Type
- Tablet
- Medication
Therapeutic class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Indications
- To reduce total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
- To reduce elevated cholesterol and triglycerides in patient with mixed dyslipidemia (Fredrickson Type Ia and Ib)
- For the treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia (Fredrickson Type IV)
- For the treatment of patients with dysbetalipoproteinaemia (Fredrickson Type III)
- To reduce cardiac ischaemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease with elevated LDL-cholesterol level
- To reduce total and LDL-cholesterol concentrations patients with hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases the number of hepatic LDL receptors for enhanced uptake and catabolism of LDL
- Rapidly absorbed after oral administration with maximum plasma concentrations within 1 to 2 hours
Absorption
- Rapid absorption after oral administration
- Maximum plasma concentrations occur within 1 to 2 hours
- Extent of absorption increases with dose
- Absolute bioavailability of Atorvastatin (parent drug) is approximately 14%
Distribution
- Mean volume of distribution is approximately 381 liters
- Atorvastatin is 98% bound to plasma proteins
- Poor drug penetration into red blood cells with a blood/plasma ratio of approximately 0.25
Metabolism
- Extensively metabolized to ortho- and parahydroxylated derivatives
- In vitro inhibition of HMG-CoA reductase by metabolites is equivalent to that of Atorvastatin
- Approximately 70% of circulating inhibitory activity for HMG-CoA reductase is attributed to active metabolites
Excretion
- Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
- Mean plasma elimination half-life of Atorvastatin in humans is approximately 14 hours
Dosage administration
- Usually 10 mg once daily for adults in primary hypercholesterolaemia and combined hyperlipidaemia
- Initially 10 mg daily for adults in familial hypercholesterolaemia, increased if necessary at intervals of at least 4 weeks to 40 mg once daily
- Initially 10 mg once daily for children (10-18 years), increased if necessary at intervals of at least 4 weeks
Interaction
- Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
- Antacid coadministration decreases plasma concentrations of atorvastatin while LDL-C reduction remains unaltered
- Colestipol coadministration decreases plasma concentrations of atorvastatin with greater LDL-C reduction than when either drug was given alone
Contraindications
- Hypersensitivity to any component of this medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy lactation
- Contraindicated during pregnancy
- Not known if excreted in human milk
- Atorvastatin should not be used in women who are pregnant, trying to become pregnant or suspect they are pregnant
- Treatment with atorvastatin should be suspended for the duration of pregnancy or until it has been determined that the woman is not pregnant
Precautions warnings
- Liver function tests should be performed before the initiation of treatment and periodically thereafter
- Used with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
- Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected
Special populations
- Plasma concentrations of Atorvastatin are higher in healthy elderly subjects than in young adults
- No clinically significant difference in LDL-C reduction with Atorvastatin between men and women
- Renal disease has no influence on the plasma concentrations or LDL-C reduction of Atorvastatin
Overdose effects
- Specific treatment is not available for Atorvastatin overdose
- Treated symptomatically and supportive measures instituted
- Liver function tests should be performed and serum CK levels monitored
Storage conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical structure
- Molecular Formula: C33H35FN2O5
Common questions
- What is TCL-R 20 mg Tablet?
- How should I take TCL-R 20 mg Tablet?
- What are the uses of TCL-R 20 mg Tablet?
- What are the Side Effects of TCL-R 20 mg Tablet?
- What are the instructions for storage and disposal of TCL-R 20 mg Tablet?
- Is TCL-R 20 mg Tablet used for lowering cholesterol?
- Will taking TCL-R 20 mg Tablet increase my risk of diabetes?
- For how long do I need to take TCL-R 20 mg Tablet? Is it safe for long-term use?
- Does TCL-R 20 mg Tablet cause weight loss?
- Can I stop taking TCL-R 20 mg Tablet?
- Does TCL-R 20 mg Tablet cause memory loss?
- Does TCL-R 20 mg Tablet make you tired?
- Can TCL-R 20 mg Tablet be prescribed to children?
- Is TCL-R 20 mg Tablet a blood thinner?
- Quick Tips: TCL-R 20 mg Tablet is safe, may cause diarrhea or an upset stomach, inform doctor if experience fatigue, muscle weakness or pain, check liver function, inform about kidney or liver disease and diabetes, not for pregnant or breastfeeding women