TCL-R 10 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Aristopharma ltd |
| Also available as |
Brand
- TCL-R
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Dosage Form
- Tablet
Indications
- Reduction of total cholesterol and LDL cholesterol in patients with familial hypercholesterolaemia
- Treatment of mixed dyslipidemia
- Treatment of hypertriglyceridaemia
- Reduction of cardiac ischaemic events in patients with coronary artery disease
- Treatment of hypercholesterolemia associated with diabetes mellitus or renal transplantation
Mode of Action
- Selective inhibition of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL
Absorption
- Rapidly absorbed after oral administration
- Maximum plasma concentrations occur within 1 to 2 hours
Distribution
- Mean volume of distribution of Atorvastatin is approximately 381 liters
- Atorvastatin is 98% bound to plasma proteins
Metabolism
- Extensively metabolized to ortho- and parahydroxylated derivatives
- Cytochrome P450 3A4 plays a role in Atorvastatin metabolism
Excretion
- Eliminated primarily in bile following metabolism
- Mean plasma elimination half-life is approximately 14 hours
Adult Dosage
- Usually 10 mg once daily; may be increased to max. 80 mg once daily if necessary
Pediatric Dosage
- Child (10-18 years): Initially 10 mg once daily, increased if necessary to max. 20 mg once daily
Interaction with Drugs
- Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
Contraindications
- Hypersensitivity to any component of the medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy
- Contraindicated during pregnancy
- Safety in pregnant women not established
- Maternal treatment may reduce fetal levels of mevalonate
Lactation
- Not known whether excreted in human milk
- Contraindicated during breastfeeding
Precautions
- Liver function tests should be performed before initiation of treatment and periodically thereafter
Geriatric Use
- Plasma concentrations are higher in healthy elderly subjects
- Greater degree of LDL-lowering in the elderly patient population
Pediatric Use
- Pharmacokinetic data not available for the pediatric population
Gender Use
- No clinically significant difference in LDL-C reduction between men and women
Renal Insufficiency
- No influence on plasma concentrations or LDL-C reduction
- Dose adjustment not necessary
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
- Chemical Structure: Image available
Common Questions
- What is TCL-R 10 mg Tablet?
- How should I take TCL-R 10 mg Tablet?
- What are the uses of TCL-R 10 mg Tablet?
- What are the Side Effects of TCL-R 10 mg Tablet?
- What are the instructions for storage and disposal of TCL-R 10 mg Tablet?
- Is TCL-R 10 mg Tablet used for lowering cholesterol?
- Will taking TCL-R 10 mg Tablet increase my risk of diabetes?
- For how long do I need to take TCL-R 10 mg Tablet? Is it safe for long-term use?
- Does TCL-R 10 mg Tablet cause weight loss?
- Can I stop taking TCL-R 10 mg Tablet?
- Does TCL-R 10 mg Tablet cause memory loss?
- Does TCL-R 10 mg Tablet make you tired?
- Can TCL-R 10 mg Tablet be prescribed to children?
- Is TCL-R 10 mg Tablet a blood thinner?
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