B-Mycin (5 mg+500 IU)/gm (Ointment)

Indications

• Topical bacterial infections
• Atopic dermatitis
• Contact dermatitis
• Stasis dermatitis
• Eczematoid dermatitis
• Neurodermatitis
• Eczema
• Anogenital pruritus
• Pyodermas
• Impetigo

Pharmacology

• Bacitracin inhibits bacterial cell wall synthesis
• Active against gram-positive bacteria
• Active against some gram-negative bacteria
• Neomycin binds to bacterial ribosome
• Inhibits protein synthesis
• Disrupts DNA synthesis
• Active against gram-negative aerobes
• Active against some strains of staphylococci

Dosage & Administration

• Ointment application after gentle cleaning
• Apply 2-3 times daily
• Dusting powder for superficial skin infections
• Apply up to 4 times daily

Interaction

• Bacitracin Zinc increased risk of nephrotoxicity
• May enhance the action of neuromuscular-blocking agents
• Neomycin Sulphate additive nephrotoxic effect
• Additive neurotoxic effect with other aminoglycosides
• May impair the absorption of other drugs
• May enhance the effect of acarbose
• May enhance the effect of non-depolarising muscle relaxants

Contraindications

• Hypersensitivity to any component

Side Effects

• Well tolerated
• Rare allergic reactions

Pregnancy & Lactation

• Use during pregnancy if benefit justifies potential risk to fetus

Precautions & Warnings

• Avoid use on large open wounds or severely injured skin
• Avoid use on areas that exude large volumes of fluid
• Avoid use for treatment of otitis external with perforated eardrum
• Consult physician for deep or puncture wounds, animal bites, or serious burns
• Discontinue use and consult physician if condition persists or worsens
• Not recommended for use in neonates

Use in Special Populations

• Suitable for use in children at adult dose
• Dose should be reduced in infants
• Not recommended for use in neonates

Therapeutic Class

• Ophthalmic and Topical antibacterial products

Storage Conditions

• Keep out of reach of children
• Store in a cool, dry place
• Protect from light

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