Nebazin (5 mg+500 IU)/gm (Ointment)

20 gm tube: ৳ 43.90

Medicine Details

Category Details
Generic Neomycin sulfate bacitracin zinc
Company Incepta pharmaceuticals ltd

Indications

  • Treatment of topical bacterial infections
  • Effective in atopic, contact stasis and infections
  • Useful in eczematoid dermatitis, neurodermatitis, eczema, anogenital pruritus
  • Adjunct in certain pyodermas such as impetigo

Pharmacology

  • Bacitracin inhibits bacterial cell wall synthesis
  • Active against gram-positive bacteria
  • Neomycin binds to bacterial ribosome, inhibiting protein synthesis
  • Active against gram negative aerobes including some strains of staphylococci

Dosage & Administration

  • Ointment application: two to three times daily
  • Dusting powder application: up to 4 times daily

Interaction

  • Increased risk of nephrotoxicity with other nephrotoxic drugs
  • May enhance the action of neuromuscular-blocking agents
  • Additive nephrotoxic and neurotoxic effect with other aminoglycosides and specific drugs
  • Enhanced toxicity with potent diuretics
  • May impair the absorption of other drugs
  • May enhance the effect of acarbose and non-depolarising muscle relaxants
  • May antagonize the parasympathomimetic effect of neostigmine and pyridostigmine

Contraindications

  • Hypersensitivity to any of its components

Side Effects

  • Usually well tolerated
  • Rare cases of allergic reactions

Pregnancy & Lactation

  • Use during pregnancy only if potential benefit justifies the potential risk to the fetus

Precautions & Warnings

  • Avoid use on large open wounds or severely injured skin, or areas exuding large volumes of fluid
  • Avoid use for otitis externa when the eardrum is perforated
  • Consult physician for deep or puncture wounds, animal bites, or serious burns
  • Discontinue use and consult physician if condition persists or worsens in minor skin injuries
  • Not recommended for use in neonates

Use in Special Populations

  • Suitable for use in children at the same dose as adults
  • Dose should be reduced in infants
  • Not recommended for use in neonates

Therapeutic Class

  • Ophthalmic and Topical antibacterial products

Storage Conditions

  • Store in a cool and dry place, protected from light
  • Keep out of reach of children

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