Neocin (5 mg+500 IU)/gm (Ointment)

20 gm tube: ৳ 44.00

Medicine Details

Category Details
Generic Neomycin sulfate bacitracin zinc
Company Opsonin pharma ltd
Also available as
Neocin 5 mg powder

Indications

  • Treatment of topical bacterial infections
  • Effective in atopic, contact stasis and infections, eczematoid dermatitis, neurodermatitis, eczema, anogenital pruritus
  • Adjunct in certain pyodermas such as impetigo
  • May be used during specific systemic antibiotic therapy for infections

Pharmacology

  • Bacitracin inhibits bacterial cell wall synthesis
  • Active against gram-positive bacteria and some gram-negative species
  • Neomycin binds to the bacterial ribosome, inhibiting protein synthesis and disrupting DNA synthesis
  • Active against gram-negative aerobes and some strains of staphylococci

Dosage & Administration

  • Ointment for application 2-3 times daily
  • Application after gentle cleaning of affected area
  • Dusting powder for superficial skin infections
  • Light dusting applied up to 4 times daily

Interaction

  • Bacitracin Zinc: Increased risk of nephrotoxicity with other nephrotoxic drugs, may enhance the action of neuromuscular-blocking agents
  • Neomycin Sulphate: Additive nephrotoxic and neurotoxic effect with other aminoglycosides, enhanced toxicity with potent diuretics, impaired absorption of other drugs, enhanced effect of acarbose, non-depolarising muscle relaxants, antagonized effect of neostigmine and pyridostigmine, increased risk of hypocalcaemia, alteration of INR, inactivation of oral typhoid vaccine

Contraindications

  • Hypersensitivity to any of its components

Side Effects

  • Usually well tolerated
  • Rare cases of allergic reactions

Pregnancy & Lactation

  • Safe use not established during pregnancy & lactation
  • Use during pregnancy only if potential benefit justifies potential risk to the fetus

Precautions & Warnings

  • Not to be used on large open wounds or severely injured skin
  • Avoid use on areas exuding large volumes of fluid
  • Not for treatment of otitis external with perforated eardrum
  • Consult physician for deep or puncture wounds, animal bites, or serious burns
  • Discontinue and consult physician if condition persists or worsens
  • Not for use longer than 1 week without physician's direction

Use in Special Populations

  • Suitable for use in children at adult dose, dose should be reduced in infants
  • Not recommended for use in neonates

Therapeutic Class

  • Ophthalmic and topical antibacterial products

Storage Conditions

  • Keep out of reach of children
  • Store in cool and dry place, protected from light

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