Bentol 1% (Cream)
10 gm tube: ৳ 11.38
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Doctors chemical works ltd |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds
Pharmacology
- Silver Sulfadiazine's mechanism of antibacterial action
- Structural changes in bacterial cell membrane
- Weakening of the cell wall membrane
- Reduced viability in sensitive strains
- Dissociation of silver sulfadiazine molecule
- Binding of silver moiety to bacterial cells
- Prevention of bacterial cell proliferation
- Urinary excretion of sulfadiazine
Dosage & Administration
- Cleansing of burn wounds before application
- Application over burn wound
- Coverage of burn areas with Silver Sulfadiazine at all times
- Recommended thickness of application
- Frequency of application
- Use of dressings if necessary
- Continuation of treatment until satisfactory healing
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Increased incidence of leukopenia with cimetidine co-administration
Contraindications
- Hypersensitivity to the drug or any of the ingredients
- Use on pregnant women approaching or at term
- Use on premature or newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Consideration of drug use during pregnancy
- Uncertainty about excretion in human milk
- Need for decision regarding nursing
Precautions & Warnings
- Impaired hepatic and renal functions
- Accumulation with decreased elimination
- Possible inactivation of topical proteolytic enzymes
- Monitoring serum sulfa concentrations
- Renal function monitoring
- Check for sulfa crystals in urine
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Temperature requirement below 30°C
- Protection from light & moisture
- Keep out of the reach of children