G-Silver Sulfadiazine 1% (Cream)
25 gm tube: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Gonoshasthaya pharma ltd |
Indications
- Topical prophylaxis against bacterial colonization in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds other than burns
Pharmacology
- Structural changes in bacterial cell membrane
- Weakened bacterial cell wall membrane
- Reduced viability in sensitive bacterial strains
- Silver sulfadiazine molecule dissociation
- Binding of silver moiety to bacterial cells and DNA
- Bacteriostatic action against sensitive organisms
- Approximately 10% absorption in adults
- Excretion of 60-85% absorbed amount in urine
Dosage & Administration
- Cleansing of burn wounds before application
- Application of Silver Sulfadiazine over burn wound
- Coverage of burn areas with Silver Sulfadiazine
- Reapplication once to twice daily
- Cream thickness of approximately 1/16 inches or 1.5 mm
- Use of dressings if necessary
- Reapplication after hydrotherapy
- Continued treatment until satisfactory healing or graft readiness
- Avoid withdrawal from therapeutic regimen in case of infection
Interaction
- Inactivation of enzymatic debriding agents
- Potentiated action of oral hypoglycemic agents and phenytoin
- Increased leukopenia incidence with co-administration of Cimetidine
Contraindications
- Hypersensitivity to the drug or its ingredients
- Pregnant women approaching or at term
- Premature infants
- Newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Use during pregnancy only if clearly justified
- Not known if excreted in human milk
- Consideration for discontinuing nursing or the drug
Precautions & Warnings
- Possible inactivation of topical proteolytic enzymes
- Accumulation upon hepatic and renal impairment
- Monitoring of serum sulfa concentrations in extensive burn wounds
- Careful monitoring of renal function and urine for sulfa crystals
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children