Medizen 1% (Cream)
25 gm tube: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Pharmasia limited |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds other than burns
Pharmacology
- Silver Sulfadiazine's antibacterial action mechanism not fully elucidated
- Structural changes in bacterial cell membrane occur after exposure to the drug
- Silver sulfadiazine dissociates and the silver moiety is bound to bacterial cells
- Silver moiety is attached to bacterial DNA preventing bacterial cell proliferation
- Sulfadiazine moiety provides bacteriostatic action against sensitive organisms
- Approximately 10% of sulfadiazine may be absorbed in adults
- Approximately 60-85% of absorbed amount is excreted in urine
Dosage & Administration
- Cleanse burn wounds before applying Silver Sulfadiazine
- Apply Silver Sulfadiazine once to twice daily to a thickness of approximately 1/16 inches or 1.5 mm
- Reapply cream to any areas removed by patient activity
- Use dressings if necessary
- Reapply immediately after hydrotherapy
- Continue treatment until satisfactory healing occurs or until the burn site is ready for grafting
Interaction
- Medizen may inactivate enzymatic debriding agents
- Concomitant use of oral hypoglycemic agents and phenytoin may be inappropriate
- Co-administration of Cimetidine may increase the incidence of leukopenia
Contraindications
- Hypersensitivity to the drug or any other ingredients
- Use is contraindicated in pregnant women approaching or at term, premature infants, or newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Use during pregnancy only if clearly justified
- Not known if Silver Sulfadiazine is excreted in human milk
- Safety and effectiveness not established in pediatric patients
Precautions & Warnings
- Consider possibility of silver inactivating proteolytic enzymes
- Discontinuation if hepatic and renal functions become impaired
- Monitor serum sulfa concentrations in patients with extensive burn wounds
- Monitor renal function and check urine for sulfa crystals
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Keep below 30°C temperature
- Store away from light and moisture
- Keep out of the reach of children