Neozine 1% (Cream)
25 gm tube: ৳ 30.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Opsonin pharma ltd |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds, other than burns
Pharmacology
- Silver Sulfadiazine's antibacterial action mechanism
- Structural changes in bacterial cell membrane
- Weakening of the cell wall membrane
- Reduced viability in sensitive strains
- Dissociation of the silver sulfadiazine molecule
- Binding of silver moiety to bacterial cells
- Prevention of bacterial cell proliferation
- Detachment of silver moiety to deoxyribonucleic acid (DNA)
- Bacteriostatic action provided by sulfadiazine moiety
- Absorption and excretion percentages in adults and children
Dosage & Administration
- Cleansing of burn wounds
- Application of Silver Sulfadiazine over the burn wound
- Coverage of burn areas with Silver Sulfadiazine
- Recommended thickness and frequency of cream application
- Reapplication to areas removed by patient activity
- Use of dressings if necessary
- Continuation of treatment until satisfactory healing or readiness for grafting
- Prevention of withdrawal from therapeutic regimen
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Potential leukopenia incidence with co-administration of Cimetidine
Contraindications
- Hypersensitivity to the product or its ingredients
- Use on pregnant women approaching or at term
- Use on premature infants
- Use on newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Consideration for use during pregnancy
- Unknown excretion in human milk
- Consideration for nursing discontinuation
Precautions & Warnings
- Impaired hepatic and renal functions
- Possible inactivation of topical proteolytic enzymes
- Monitoring of serum sulfa concentrations
- Careful monitoring of renal function and urine for sulfa crystals
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Temperature below 30°C
- Protection from light and moisture
- Keep out of the reach of children