Sibalyn 1% (Cream)
25 gm tube: ৳ 40.12
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Aci limited |
Indications
- Topical prophylaxis against bacterial colonization in burn wounds
- Topical antibacterial management of contaminated wounds
Pharmacology
- Silver Sulfadiazine's mechanism of antibacterial action
- Structural changes in bacterial cell membrane
- Weakening of cell wall membrane
- Inhibition of bacterial cell proliferation
- Approximately 10% absorption in adults
- Excretion in urine
Dosage & Administration
- Application on cleansed burn wounds
- Application thickness of approximately 1/16 inches
- Reapplication after patient activity or hydrotherapy
- Continued treatment until satisfactory healing
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Increased incidence of leukopenia with Cimetidine co-administration
Contraindications
- Hypersensitivity to the drug or its ingredients
- Pregnant women approaching or at term
- Premature infants
- Newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Excretion in human milk unknown
- Consideration of drug discontinuation during nursing
Precautions & Warnings
- Impaired hepatic and renal functions
- Possibility of silver inactivating proteolytic enzymes
- Monitoring of serum sulfa concentrations
- Careful monitoring of renal function and urine for sulfa crystals
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children