Silburn 1% (Cream)
20 gm tube: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Pharmadesh laboratories ltd |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds
Pharmacology
- Mechanism of Silver Sulfadiazine's antibacterial action
- Structural changes in bacterial cell membrane
- Binding of silver moiety to bacterial cells
- Prevention of bacterial cell proliferation
- Bacteriostatic action against sensitive organisms
- Absorption and excretion in adults and children
Dosage & Administration
- Application process for burn wounds
- Frequency and thickness of application
- Use of dressings if necessary
- Continuation of treatment until healing or grafting
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Increased incidence of leukopenia with cimetidine co-administration
Contraindications
- Hypersensitivity to the drug or its ingredients
- Use on pregnant women, premature infants, or newborns within the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Category B pregnancy classification
- Consideration for use during pregnancy and lactation
- Safety and effectiveness in pediatric patients not established
Precautions & Warnings
- Consideration in cases of hepatic and renal impairment
- Possible inactivation of topical proteolytic enzymes
- Monitoring of serum sulfa concentrations in extensive burn wounds
- Monitoring of renal function and urine for sulfa crystals
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Temperature, light, and moisture considerations
- Safety protocol for keeping out of reach of children