Silcream 1% (Cream)
5 gm tube: ৳ 14.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Jayson pharmaceuticals ltd |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds
Pharmacology
- Antibacterial action on bacterial cell membrane
- Structural changes in bacterial cell membrane
- Weakening of bacterial cell wall membrane
- Binding of silver moiety to bacterial cells
- Inhibition of bacterial cell proliferation
- Bacteriostatic action against sensitive organisms
- Approximately 10% absorption in adults
- Approximately 60-85% excretion in urine
Dosage & Administration
- Application over burn wounds
- Covering burn areas with Silver Sulfadiazine at all times
- Application once to twice daily
- Thickness of approximately 1/16 inches or 1.5 mm
- Reapplication to areas removed by patient activity
- Use of dressings if necessary
- Reapplication after hydrotherapy
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Increase in leukopenia incidence with co-administration of Cimetidine
Contraindications
- Hypersensitivity to the product or its ingredients
- Use on pregnant women approaching or at term
- Use on premature or newborn infants within the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Justified use during pregnancy
- Unknown excretion in human milk
- Consideration for nursing mothers
Precautions & Warnings
- Impaired hepatic and renal functions
- Inactivation of topical proteolytic enzymes
- Monitoring of serum sulfa concentrations
- Careful monitoring of renal function
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children