Silvadazin 1% (Cream)
25 gm tube: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Aristopharma ltd |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds
Pharmacology
- Silver Sulfadiazine's antibacterial action mechanism
- Structural changes in bacterial cell membrane
- Weakening of cell wall membrane
- Reduction in viability of sensitive strains
- Dissociation of silver sulfadiazine molecule
- Binding of silver moiety to bacterial cells
- Prevention of bacterial cell proliferation by silver moiety
- Bacteriostatic action of sulfadiazine moiety
- Approximately 10% absorption in adults
- 60-85% excretion in urine
- 31.8 mg/L urinary sulfadiazine concentration in children with 13% body surface area burns
Dosage & Administration
- Cleansing of burn wounds before application
- Application to thickness of 1/16 inches or 1.5 mm
- Reapplication after patient activity or removal
- Use of dressings if necessary
- Reapplication after hydrotherapy
- Continued treatment until healing or grafting readiness
- No withdrawal from therapeutic regimen in case of infection possibility
- Do not use on pregnant women, premature infants, or newborns within first 2 months of life
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Increased incidence of leukopenia with cimetidine co-administration
Contraindications
- Hypersensitivity to the drug or its ingredients
- Use on pregnant women approaching or at term
- Use on premature infants
- Use on newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Considerations for use during pregnancy
- Unknown excretion in human milk
- Decision for nursing discontinuation or drug discontinuation
- No established safety and effectiveness in pediatric patients
Precautions & Warnings
- Monitoring of hepatic and renal functions
- Discontinuation in case of impaired functions and drug accumulation
- Possibility of silver inactivating proteolytic enzymes
- Monitoring of serum sulfa concentrations in extensive burn wounds
- Careful renal function monitoring and sulfa crystal check in urine
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Storage below 30°C
- Protection from light and moisture
- Keep out of reach of children