Afun 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Square pharmaceuticals plc |
Indications
- All dermatomycoses due to dermatophytes
- All dermatomycoses due to yeasts
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with fungi
- Interdigital mycoses (e.g. athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
A broad-spectrum antifungal agent for dermal infections caused by various pathogenic dermatophytes, yeasts, moulds, and bacteroids. Active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Alters permeability of fungal cell walls and inhibits ergosterol synthesis.
Pharmacology
Damages the permeability barrier in the cell membrane of fungi. Causes inhibition of ergosterol biosynthesis. Inhibits lanosterol 14-demethylase (CYP51). Other effects include the inhibition of sarcoplasmic reticulum Ca2+ ATPase and depletion of intracellular calcium.
Dosage & Administration
- Clotrimazole Cream: Thinly applied 2-3 times daily to the infected sites and rubbed in. Small amount usually sufficient for an area about the size of the palm. Duration of treatment varies.
- Recommended duration of treatment:
- Dermatomycoses: 3-4 weeks
- Candida vulvitis and Candida balanitis: 1-2 weeks
- Erythrasma and Pityriasis Versicolor: 3 weeks (approximately)
- Fungal infection of the feet: To prevent relapse, treatment should be continued for about 2 weeks beyond the disappearance of all signs of disease.
Interaction
No information is available
Contraindications
Hypersensitivity to Clotrimazole
Side Effects
Well tolerated when applied topically. No observed systemic effects. Local irritation or burning sensation may occur in a very few cases.
Pregnancy & Lactation
Recommended for use in pregnancy only when considered necessary by the physician
Therapeutic Class
Drugs for subcutaneous and mycoses, Topical Antifungal preparations
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.