Clodal 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Globe pharmaceuticals ltd |
Indications
- All dermatomycoses due to dermatophytes (e.g.Trichophyton species)
- All dermatomycoses due to yeasts (Candida species)
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
- Interdigital mycoses (e.g. athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
Clodal is a broad-spectrum antifungal agent used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds and bacteroids. It is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Like other imidazoles, Clodal alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungi static levels, the main effect is inhibition of ergosterol synthesis but at higher concentrations, there is an additional mechanism of membrane damage unrelated to sterol synthesis.
Pharmacology
Acts primarily by damaging the permeability barrier in the cell membrane of fungi. Causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. Rapid onset of the above events leads to dose-dependent inhibition of fungal growth.
Dosage & Administration
- Clotrimazole Cream should be thinly applied 2-3 times daily to the infected sites and rubbed in
- Recommended duration of treatment varies depending on the extent and localization of the disease
- For fungal infection of the feet, treatment should be continued for about 2 weeks beyond the disappearance of all signs of disease
- Clotrimazole topical solution should be applied sparingly to the affected areas and rubbed in gently, two or three times daily
Interaction
No information is available.
Contraindications
Hypersensitivity to Clotrimazole
Side Effects
Well tolerated with external application, systemic effects are not observed. Local irritation or burning sensation may occur in very few cases but are not considered harmful.
Pregnancy & Lactation
Recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician
Therapeutic Class
Drugs for subcutaneous and mycoses, Topical Antifungal preparations
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children