Cloderm 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | General pharmaceuticals ltd |
Indications
- All dermatomycoses due to dermatophytes (e.g.Trichophyton species)
- All dermatomycoses due to yeasts (Candida species)
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
- Interdigital mycoses (e.g. athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
Cloderm is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds and bacteroids. Cloderm is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Like other imidazoles, Cloderm alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungi static levels the main effect is inhibition of ergosterol synthesis but at higher concentrations there is an additional mechanism of membrane damage unrelated to sterol synthesis.
Pharmacology
Acts primarily by damaging the permeability barrier in the cell membrane of fungi. Causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. Rapid onset of events leads to dose-dependent inhibition of fungal growth. Also shows other pharmacological effects including the inhibition of sarcoplasmic reticulum Ca2+ ATPase, depletion of intracellular calcium, and blocking of calcium‐dependent potassium channels and voltage‐dependent calcium channels.
Dosage & Administration
- Clotrimazole Cream: Thinly applied 2-3 times daily to the infected sites and rubbed in. Recommended duration of treatment varies for different conditions.
- Clotrimazole topical solution: Applied sparingly to the affected areas and rubbed in gently, two or three times daily.
Interaction
No information is available.
Contraindications
Hypersensitivity to Clotrimazole.
Side Effects
Well tolerated when applied topically. Local irritation or burning sensation may occur in a very few cases but these symptoms are not considered harmful.
Pregnancy & Lactation
Recommended to be used in pregnancy only when considered necessary by the physician.
Therapeutic Class
- Drugs for subcutaneous and mycoses
- Topical Antifungal preparations
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.