Clotrim 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Acme laboratories ltd |
Indications
- All dermatomycoses due to dermatophytes (e.g. Trichophyton species)
- All dermatomycoses due to yeasts (Candida species)
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
- Interdigital mycoses (e.g. athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
Clotrim is a broad-spectrum antifungal agent used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds, and bacteroids. It is also active against certain gram-positive bacteria, especially Staphylococci and Tricomonas. Clotrim alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungistatic levels, the main effect is the inhibition of ergosterol synthesis, but at higher concentrations, there is an additional mechanism of membrane damage unrelated to sterol synthesis.
Pharmacology
Clotrimazole primarily damages the permeability barrier in the cell membrane of fungi. It causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane. Because ergosterol directly promotes the growth of fungal cells in a hormone-like fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth. Clotrimazole also shows other pharmacological effects such as the inhibition of sarcoplasmic reticulum Ca2+ ATPase, depletion of intracellular calcium, and blocking of calcium-dependent potassium channels and voltage-dependent calcium channels.
Dosage & Administration
- Clotrimazole Cream: Thinly apply 2-3 times daily to the infected sites and rub in. A small amount of cream is usually sufficient for an area about the size of the palm. Duration of treatment varies depending on factors such as extent and localization of the disease.
- Clotrimazole topical solution: Apply sparingly to the affected areas and rub in gently, two or three times daily.
Interaction
No information available
Contraindications
Hypersensitivity to Clotrimazole
Side Effects
When applied topically, Clotrim is well-tolerated. With external application, systemic effects are not observed. Local irritation or burning sensation may occur in very few cases but these symptoms are not considered harmful.
Pregnancy & Lactation
It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician.
Therapeutic Class
Drugs for subcutaneous and mycoses, Topical Antifungal preparations
Storage Conditions
Keep below 25°C temperature, away from light and moisture. Keep out of the reach of children.