Tiginor 10 mg (Tablet)

Unit Price: ৳ 11.50 (3 x 10: ৳ 345.00)

Strip Price: ৳ 115.00

Medicine Details

Category	Details
Generic	Atorvastatin calcium
Company	Incepta pharmaceuticals ltd
Also available as	Tiginor 20 mg tablet Tiginor 40 mg tablet

Title

Tiginor 10 mg Tablet

Description

Tiginor 10 mg Tablet is indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various diseases when response to diet and other non-pharmacological measures is inadequate. Atorvastatin, the active ingredient, is a selective inhibitor of HMG-CoA reductase, which is the rate-limiting enzyme responsible for the conversion of HMG-CoA to mevalonate, a precursor of sterols, including cholesterol. It lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and increases the number of hepatic LDL receptors for enhanced uptake and catabolism of LDL.

Dimensions

N/A

Color Options

N/A

Function

Reduce elevated total cholesterol
Reduce elevated LDL cholesterol
Reduce apolipoprotein B levels
Reduce triglycerides levels
Enhance uptake and catabolism of LDL cholesterol

Materials

N/A

Technical Specifications

Absorption: Atorvastatin is rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours.
Distribution: Mean volume of distribution of Atorvastatin is approximately 381 liters; it is 98% bound to plasma proteins.
Metabolism: Atorvastatin is extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products.

Design Elements

N/A

Usability Features

Used as a single dose at any time of the day, with or without food
Dosage range of Atorvastatin is 10 to 80 mg once daily
Analysis of lipid levels within 2 to 4 weeks after initiation of Atorvastatin

Indications

Reduce cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
Reduce cholesterol and triglycerides in patient with mixed dyslipidemia
Treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia
Treatment of patients with dysbetalipoproteinaemia
Reduce cardiac ischaemic events in patients with coronary artery disease
Reduce cholesterol concentrations in patients with hypercholesterolemia associated with diabetes mellitus or renal transplantation

Dosage and Administration

Recommended starting dose of Atorvastatin is 10 or 20 mg once daily
Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily
Dosage range of Atorvastatin is 10 to 80 mg once daily
Doses should be individualized according to the recommended goal of therapy

Interaction

Elevated plasma concentrations of atorvastatin when coadministered with cyclosporine, fibric acid derivatives, niacin, and erythromycin
Decreased plasma concentrations of atorvastatin when coadministered with antacids and colestipol
Increased plasma concentrations of digoxin when coadministered with atorvastatin
Increased plasma concentrations of atorvastatin when coadministered with erythromycin
Increased AUC values for oral contraceptives when coadministered with atorvastatin

Contraindications

Hypersensitivity to any component of this medication
Active liver disease or unexplained persistent elevations of serum transaminases
History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

Constipation
Flatulence
Dyspepsia
Abdominal pain
Infection
Headache
Back pain
Rash
Asthenia
Arthralgia
Myalgia

Pregnancy and Lactation

Contraindicated during pregnancy
Not known whether atorvastatin or its metabolites are excreted in human milk
Maternal treatment with atorvastatin may reduce fetal levels of mevalonate
Treatment with atorvastatin should be suspended during pregnancy or until pregnancy is ruled out

Precautions and Warnings

Liver function tests should be performed before the initiation of treatment and periodically thereafter. Tiginor should be used with caution in patients who consume substantial quantities of alcohol or have a history of liver disease.

Use in Special Populations

Geriatric: Plasma concentrations of Tiginor are higher in healthy elderly subjects than in young adults
Pediatric: Pharmacokinetic data in the pediatric population are not available
Gender: No clinically significant difference in LDL-C reduction with Tiginor between men and women
Renal Insufficiency: No influence on the plasma concentrations or LDL-C reduction of Tiginor
Hemodialysis: Not expected to significantly enhance clearance of Tiginor
Hepatic Insufficiency: Plasma concentrations of Tiginor are markedly increased in patients with chronic alcoholic liver disease

Overdose Effects

Specific treatment is not available for atorvastatin overdose. Symptomatic treatment and supportive measures may be instituted.

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs
Statins

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Chemical Structure

Molecular Formula: C33H35FN2O5
Chemical Structure Image: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Commonly Asked Questions

What is Tiginor 10 mg Tablet?
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What are the instructions for storage and disposal Tiginor 10 mg Tablet?
Is Tiginor 10 mg Tablet used for lowering cholesterol?
Will taking Tiginor 10 mg Tablet increase my risk of diabetes?
For how long do I need to take Tiginor 10 mg Tablet? Is it safe for long-term use?
Does Tiginor 10 mg Tablet cause weight loss?
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Does Tiginor 10 mg Tablet make you tired?
Can Tiginor 10 mg Tablet be prescribed to children?
Is Tiginor 10 mg Tablet a blood thinner?
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