Clozox 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Unimed unihealth pharmaceuticals ltd |
Indications
- All dermatomycoses due to dermatophytes
- Dermatomycoses due to yeasts
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
- Interdigital mycoses (e.g. athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
Clozox is a broad-spectrum antifungal agent used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds, and bacteroids. It is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Clozox alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungistatic levels, the main effect is inhibition of ergosterol synthesis, but at higher concentrations, there is an additional mechanism of membrane damage unrelated to sterol synthesis.
Pharmacology
Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. It causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane.
Mode of Action
- Alters the permeability of fungal cell walls
- Inhibits ergosterol biosynthesis
- Damages the permeability barrier in the cell membrane of fungi
Dosage & Administration
- Clotrimazole Cream: Thinly apply 2-3 times daily to the infected sites and rub in. Reliable and sufficiently long-time application is important for complete success. Duration varies based on the extent and localization of the disease. Recommended duration of treatment: Dermatomycoses - 3-4 weeks, Candida vulvitis and Candida balanitis - 1-2 weeks, Erythrasma and Pityriasis Versicolor - 3 weeks (approximately)
- Clotrimazole topical solution: Apply sparingly to the affected areas and rub in gently, two or three times daily
Interaction
No information is available
Contraindications
Hypersensitivity to Clotrimazole
Side Effects
Well tolerated with external application; systemic effects not observed. Local irritation or burning sensation may occur in very few cases but these symptoms are not considered harmful
Pregnancy & Lactation
Use in pregnancy only when considered necessary by the physician
Therapeutic Class
Drugs for subcutaneous and mycoses, Topical Antifungal preparations
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children