Dermasim 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Aci limited |
| Also available as |
Indications
- Dermal infections caused by dermatophytes
- Dermal infections caused by yeasts
- Dermal infections caused by moulds
- Superinfections with fungi
- Interdigital mycoses
- Paronychias
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
Broad-spectrum antifungal agent for dermal infections caused by dermatophytes, yeasts, moulds, and bacteroids. Active against gram-positive bacteria, especially Staphylococci and Tricomonas. Alters permeability of fungal cell walls by interfering with cell wall lipids. Inhibits ergosterol synthesis and causes membrane damage unrelated to sterol synthesis.
Pharmacology
- Damages permeability barrier in fungal cell membrane
- Inhibits ergosterol biosynthesis
- Inhibition of lanosterol 14-demethylase (CYP51)
- Inhibits sarcoplasmic reticulum Ca^2+ ATPase
- Depletes intracellular calcium
- Blocks calcium-dependent potassium channels
- Blocks voltage-dependent calcium channels
Dosage & Administration
- Thinly apply 2-3 times daily
- Treatment duration varies based on disease
- Recommended duration of treatment for specific infections
Interaction
No information available
Contraindications
Hypersensitivity to Clotrimazole
Side Effects
Well tolerated when applied topically, no systemic effects observed, may cause local irritation or burning sensation in very few cases
Pregnancy & Lactation
Recommended for use in pregnancy only when considered necessary by physician
Therapeutic Class
Drugs for subcutaneous and mycoses, Topical Antifungal preparations
Storage Conditions
Keep below 25°C, away from light & moisture, keep out of the reach of children