Loderm 1% (Cream)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Ad din pharmaceuticals ltd |
Indications
- All dermatomycoses due to dermatophytes (e.g.Trichophyton species)
- All dermatomycoses due to yeasts (Candida species)
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
Description
Loderm is a broad-spectrum antifungal agent used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds and bacteroids. It is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Loderm alters the permeability of fungal cell walls by interfering with cell wall lipids. It inhibits ergosterol synthesis and causes membrane damage unrelated to sterol synthesis at higher concentrations.
Pharmacology
- Clotrimazole damages the permeability barrier in the cell membrane of fungi
- It inhibits ergosterol biosynthesis
- Inhibition of lanosterol 14-demethylase leads to dose-dependent inhibition of fungal growth
- Inhibition of sarcoplasmic reticulum Ca^2+ ATPase
- Depletion of intracellular calcium
- Blocking of calcium-dependent potassium channels and voltage-dependent calcium channels
Dosage & Administration
- Clotrimazole Cream: Thinly applied 2-3 times daily to the infected sites and rubbed in. Recommended duration of treatment varies based on the condition. Treatment for fungal infection of the feet should be continued for about 2 weeks beyond the disappearance of all signs of disease. Odorless and can be washed off without staining clothing.
- Clotrimazole topical solution: Applied sparingly to the affected areas and rubbed in gently, two or three times daily
Interaction
No information is available
Contraindications
Hypersensitivity to Clotrimazole
Side Effects
Well tolerated when applied topically. Local irritation or burning sensation may occur in very few cases, but these symptoms are not considered harmful.
Pregnancy & Lactation
Recommended for use in pregnancy only when considered necessary by the physician
Therapeutic Class
Drugs for subcutaneous and mycoses, Topical Antifungal preparations
Storage Conditions
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children