Binafin 1% (Cream)
10 gm tube: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Terbinafine hydrochloride |
| Company | Amulet pharmaceuticals ltd |
Indications
- Treatment of onychomycosis of the toenail or fingernail
- Treatment of Tinea Capitis
- Fungal infection of the skin caused by specific pathogens
- Indicated in the treatment of tinea infections of the skin
- Treatment of pityriasis (tinea) versicolor
Pharmacology
- Inhibition of Ergosterol biosynthesis
- Fungal cell death due to increased membrane permeability
- Activity against specific microorganisms
Dosage & Administration
- Specific dosage for onychomycosis treatment
- Different dosages based on body weight
- Application durations for different skin fungal infections
- Instructions for application of spray
Interaction
- Inhibitor of the CYP450 2D6 isozyme
- Drugs predominantly metabolized by CYP450 2D6 isozyme
- Potential requirement for dose reduction of 2D6-metabolized drugs during co-administration
Contraindications
- Contra-indicated in individuals with hypersensitivity to terbinafine
Side Effects
- Gastrointestinal symptoms
- Liver test abnormalities
- Skin reactions
- Neutropenia
- Thrombocytopenia
- Taste disturbances
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Presence in breast milk of nursing mothers
- Foetal toxicity and fertility studies in animals
- Excretion in breast milk
Precautions & Warnings
- Rare cases of liver failure
- Adverse skin reactions
- External use only for cream
- Pre-existing liver disease assessment
- Hepatotoxicity possibility
- Pretreatment serum transaminase teste
Use in Special Populations
- Safety and efficacy not established in pediatric patients
- No evidence of different dosages for elderly patients
Overdose Effects
- Clinical experience regarding overdose
- Limited adverse reactions from high doses
Therapeutic Class
- Other Antifungal preparations
- Topical Antifungal preparations
Storage Conditions
- Cool and dry place below 30°C
- Protection from light