Scabfre 5% w/w (Cream)

Indications

• Treatment of scabies and crab lice infestations

Pharmacology

• Contains Permethrin, a pyrethroid
• Acts on the nerve cell membrane to disrupt the sodium channel current
• Results in delayed repolarization & paralysis of the pests

Pharmacokinetics

• Topical route is the only approved route of administration
• Less than 0.5% of applied permethrin is absorbed during the first 48 hours
• Rapid metabolism by ester hydrolysis and excretion primarily in the urine

Dosage

• Adults and children over 12 years: a full tube
• Children aged 6-12 years: up to 1/2 of a tube
• Children aged 1-5 years: up to 1/4 of a tube
• Children aged 2 months to 1 year: up to 1/8 of a tube
• Children Less then 2 months: dose is not established

Administration

• Skin should be clean, cool and dry before application
• For adults and children over 2 years: apply to the whole body from the neck down, including between fingers and toes, under the nails, and on the soles of the feet
• For babies under 2 years: apply to face, neck, ears, and scalp, avoiding the area around the eyes and mouth
• Leave cream on for at least 8 hours before washing off
• Reapply to any washed area during the 8h treatment time, if necessary
• Reapplication after 7 days as per doctor's advice

Interaction

• Withholding treatment of eczemodous like reactions with corticosteroids prior to Scabfre use

Contraindications

• Hypersensitivity to any component of pyrethroids or permethrin

Side Effects

• Skin discomfort like burning, stinging or tingling soon after cream application
• Transient signs and symptoms of irritation including erythema, edema, eczema, rash, and pruritus

Pregnancy & Lactation

• Use in pregnancy should follow medical advice
• Not known whether permethrin is excreted in human milk, should not be used in nursing mothers

Precautions & Warnings

• Avoid contact with eyes during application
• Flash with water immediately if the cream gets in the eyes

Therapeutic Class

• Parasiticidal preparations

Storage Conditions

• Store in a cool, dry place away from light
• Keep out of the reach of children

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