Xelpid 40 mg (Tablet)
Unit Price: ৳ 24.00 (2 x 10: ৳ 480.00)
Strip Price: ৳ 240.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Title
- Xelpid 40 mg Tablet
Categories
- Cholesterol-lowering Medication
- Cardiovascular Medication
- Pharmacological Agents
Indications
- To reduce total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
- To reduce elevated cholesterol and triglycerides in patients with mixed dyslipidemia
- For the treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia
- For the treatment of patients with dysbetalipoproteinaemia
- To reduce cardiac ischaemic events in patients with coronary artery disease and elevated LDL-cholesterol level
- To reduce total and LDL-cholesterol concentrations in patients with hypercholesterolemia associated with diabetes mellitus or renal transplantation
Mode of Action
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver
- Increases the number of hepatic LDL receptors on the cell surface for enhanced uptake and catabolism of LDL
Absorption
- Rapidly absorbed after oral administration
- Maximum plasma concentrations occur within 1 to 2 hours
Metabolism
- Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
- In vitro inhibition of HMG-CoA reductase by ortho- and parahydroxylated metabolites is equivalent to that of Atorvastatin
Excretion
- Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
- Mean plasma elimination half-life of Atorvastatin in humans is approximately 14 hours
Dosage & Administration
- Adults: Usually 10 mg once daily; may be increased at intervals to max. 80 mg once daily
- Child (10-18 years): Initially 10 mg once daily, increased if necessary to usual max. 20 mg once daily
Interaction
- Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
- Altered plasma concentrations when coadministered with antacid, colestipol, digoxin, erythromycin, oral contraceptives
Contraindications
- Hypersensitivity to any component of the medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy & Lactation
- Contraindicated during pregnancy
- Not known whether excreted in human milk
- Potential for serious adverse reactions, women should not breastfeed their infants
Precautions & Warnings
- Liver function tests should be performed before initiation of treatment and periodically thereafter
- Discontinue if markedly elevated CPK levels occur or myopathy is diagnosed or suspected
Use in Special Populations
- Higher plasma concentrations in healthy elderly subjects than in young adults
- No clinically significant difference in LDL-C reduction between men and women
- Renal disease has no influence on the plasma concentrations or LDL-C reduction
- Dose adjustment in patients with renal dysfunction is not necessary
Overdose Effects
- Specific treatment not available, treated symptomatically and supportive measures instituted
- Liver function tests should be performed and serum CK levels monitored
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
- Chemical Structure: Image available
Commonly Asked Questions
- What is Xelpid 40 mg Tablet?
- How should I take Xelpid 40 mg Tablet?
- What are the uses of Xelpid 40 mg Tablet?
- What are the Side Effects of Xelpid 40 mg Tablet?
- What are the instructions for storage and disposal Xelpid 40 mg Tablet?
- Is Xelpid 40 mg Tablet used for lowering cholesterol?
- Will taking Xelpid 40 mg Tablet increase my risk of diabetes?
- For how long do I need to take Xelpid 40 mg Tablet? Is it safe for long-term use?
- Does Xelpid 40 mg Tablet cause weight loss?
- Can I stop taking Xelpid 40 mg Tablet?
- Does Xelpid 40 mg Tablet cause memory loss?
- Does Xelpid 40 mg Tablet make you tired?
- Can Xelpid 40 mg Tablet be prescribed to children?
- Is Xelpid 40 mg Tablet a blood thinner?
- Quick Tips
Extra Attribute 1
- Elevated serum triglyceride levels in hypertriglyceridaemia are treated with this medication
Extra Attribute 2
- Plasma concentrations of Xelpid are higher in healthy elderly subjects than in young adults
Extra Attribute 3
- Metabolism by cytochrome P450 3A4
Extra Attribute 4
- Administered as a single dose at any time of the day, with or without food
Extra Attribute 5
- Starting dose of 10 or 20 mg once daily, may be increased to max. 80 mg once daily
Extra Attribute 6
- Recommended for patients with hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation
Extra Attribute 7
- Atorvastatin is contraindicated during breastfeeding
Extra Attribute 8
- Plasma concentrations of Atorvastatin and its active metabolites are similar in rats and humans
Extra Attribute 9
- Use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
Extra Attribute 10
- Maximum plasma concentrations occur within 1 to 2 hours after oral administration