Clobederm 0.05% (Cream)

10 gm tube: ৳ 50.20

Medicine Details

Category Details
Generic Clobetasol propionate
Company Drug international ltd
Also available as
Clobederm 005 ointment

Indications

  • Psoriasis (excluding widespread plaque psoriasis)
  • Recalcitrant dermatoses
  • Lichen planus
  • Discoid lupus erythematosus
  • Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

  • Clobetasol Propionate Cream: 0.05% w/w
  • Clobetasol Propionate Ointment: 0.05% w/w
  • Clobetasol Propionate Scalp Application: 0.05% w/w
  • Clobetasol Propionate Shampoo: 0.05% w/w
  • Clobetasol Propionate Lotion: 0.05% w/w
  • Clobetasol Propionate Spray: 0.05% w/w

Pharmacology

Clobetasol Propionate is a very potent topical corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties.

Dosage

  • Cream, Ointment:
    • Apply a thin layer twice daily
    • Limited to 2 consecutive weeks
    • Maximum weekly dose: 50 gm
  • Spray: Apply once or twice daily; total dose applied should not exceed 50 ml weekly
  • Shampoo: Apply to dry scalp once a day; treatment limited to 4 consecutive weeks
  • Scalp Solution: Apply once or twice daily; total dose should not exceed 50 ml weekly

Administration

Route of administration: Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified or scaly lesions.

Interaction

Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids.

Contraindications

  • Rosacea, acne vulgaris and perioral dermatitis
  • Hypersensitivity to the preparation
  • Primary cutaneous viral infections
  • Dermatoses in children under one year of age

Side Effects

  • Systemic absorption
  • Atrophic changes in the skin
  • Pustular form of the disease
  • Pigmentation changes and hypertrichosis

Pregnancy & Lactation

Use during pregnancy and lactation should be considered in comparison to the expected benefit to the mother.

Precautions & Warnings

  • Long-term continuous topical therapy to be avoided
  • Atrophic changes after prolonged treatment
  • Care needed when applying to eyelids
  • Hazardous in psoriasis
  • Use in infants and children

Use in Special Populations

In infants and children under 12 years of age, long-term continuous topical corticosteroid therapy should be avoided.

Overdose Effects

Acute overdosage is very unlikely, chronic over-dosage or misuse may lead to hypercortisolism.

Therapeutic Class

  • Other Topical corticosteroids

Storage Conditions

Keep below 30°C, protected from light and moisture, do not freeze.

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