Clobenate 0.05% (Cream)

10 gm tube: ৳ 51.00

Medicine Details

Category	Details
Generic	Clobetasol propionate
Company	Jenphar bangladesh ltd
Also available as	Clobenate 005 ointment

Indications

Psoriasis (excluding widespread plaque psoriasis)
Recalcitrant dermatoses
Lichen planus
Discoid lupus erythematosus
Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

Clobetasol Propionate is a very potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. It inhibits late phase allergic reactions, decreases mast cell density, inhibits cytokine production, and more.

Dosage

Cream, Ointment: Apply a thin layer to affected skin areas twice daily for adults, elderly, and children over 1 year
Spray: Apply required quantity once or twice daily to affected areas of the scalp
Shampoo: Apply to dry scalp once a day to affected areas only, limit to 4 consecutive weeks
Scalp Solution: Apply required quantity once or twice daily to affected areas of the scalp

Administration

Route of administration: Cutaneous. Creams are especially appropriate for moist or weeping surfaces. Ointments are especially appropriate for dry, lichenified or scaly lesions.

Interaction

Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids leading to increased systemic exposure.

Contraindications

Rosacea, acne vulgaris, and perioral dermatitis
Primary cutaneous viral infections
Hypersensitivity to the preparation
The use of Clobetasol Propionate skin preparations is not indicated in the treatment of primarily infected skin lesions caused by fungi or bacteria
Dermatoses in children under one year of age

Side Effects

Prolonged use can result in systemic absorption
Local atrophic changes in the skin
Provocation of the pustular form of psoriasis
Pigmentation changes and hypertrichosis

Pregnancy & Lactation

Limited data from the use of Clobetasol Propionate cream in pregnant women. Caution should be exercised when administered to a nursing woman.

Precautions & Warnings

Long-term continuous topical therapy should be avoided especially in infants and children
Atrophic changes after prolonged treatment with potent topical corticosteroids

Use in Special Populations

In infants and children under 12 years of age, long-term continuous topical corticosteroid therapy should be avoided