Clobesol 0.05% (Ointment)
10 gm tube: ৳ 68.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Psoriasis
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Management of skin conditions not responding to less potent steroids
Composition
- Clobetasol Propionate Cream
- Clobetasol Propionate Ointment
- Clobetasol Propionate Scalp Application
- Clobetasol Propionate Shampoo
- Clobetasol Propionate Lotion
- Clobetasol Propionate Spray
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory
- Antipruritic
- Vasoconstrictive properties
- Inhibition of late phase allergic reactions
- Reduction of mast cell density
- Inhibition of eosinophil activation
- Cytokine production reduction
- Inhibition of arachidonic acid metabolism
Dosage
- Cream and Ointment application instructions
- Super-high potency corticosteroid
- Limited to 2 consecutive weeks of treatment
- Maximum weekly dose limit
- Dosage for the Spray
- Limitation of Shampoo treatment to 4 consecutive weeks
- Scalp solution application instructions
Administration
- Route of administration: Cutaneous
- Creams suitable for moist or weeping surfaces
- Ointments suitable for dry, lichenified, or scaly lesions
Interaction
- Potential inhibition of CYP3A4 by co-administered drugs
Contraindications
- Rosacea, acne vulgaris, perioral dermatitis
- Hypersensitivity to the preparation
- Not indicated for primary cutaneous viral infections
- Not recommended for dermatoses in children under one year of age
Side Effects
- Systemic absorption with prolonged use
- Local atrophic changes with intensive treatment
- Pustular form of psoriasis in rare instances
- Pigmentation changes and hypertrichosis reported
Pregnancy & Lactation
- Limited data in pregnant women
- Topical corticosteroids in pregnant animals caused fetal abnormalities
- Unknown excretion in human milk
Precautions & Warnings
- Avoid long-term continuous therapy, especially in infants and children
- Atrophic changes risk on the face with prolonged treatment
- Risk of glaucoma or cataract if applied to eyelids
- Hazardous in psoriasis for various reasons
- Use of appropriate anti-microbial therapy for infected lesions
Use in Special Populations
- Avoid long-term continuous therapy in infants and children under 12 years
Overdose Effects
- Acute overdosage unlikely
- Features of hypercortisolism with chronic over-dosage
Therapeutic Class
- Other Topical corticosteroids
Storage Conditions
- Storage below 30°C
- Protection from light and moisture
- Keep out of the reach of children