Clovate 0.05% (Ointment)
10 gm tube: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Aci limited |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
Pharmacology
Clobetasol Propionate is a very potent topical corticosteroid. It has anti-inflammatory, antipruritic, and vasoconstrictive properties. It shows anti-inflammatory activity via multiple mechanisms to inhibit late phase allergic reactions
Dosage
- Cream & Ointment: Apply a thin layer twice daily and rub in gently and completely
- Spray: Apply required quantity once or twice daily to the affected areas of the scalp and gently rub in
- Shampoo: Apply to dry scalp once a day to the affected areas only and lather and rinse after 15 minutes
- Scalp Solution: Apply required quantity once or twice daily to the affected areas of the scalp and gently rub in
Administration
Route of administration: Cutaneous
Interaction
Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids
Contraindications
- Rosacea, acne vulgaris, and perioral dermatitis
- Primary cutaneous viral infections
- Hypersensitivity to the preparation
- Skin lesions caused by infection with fungi or bacteria
- Dermatoses in children under one year of age
Side Effects
- Hypercorticism from systemic absorption
- Local atrophic changes in the skin
- Pustular form of psoriasis
- Pigmentation changes and hypertrichosis
Pregnancy & Lactation
Limited data in pregnant women. Caution in lactating women
Precautions & Warnings
- Avoid long-term continuous therapy, especially in infants and children
- Atrophic changes after prolonged treatment, especially on the face
- Care needed to prevent entry into the eye
- Hazardous in psoriasis for several reasons
- Appropriate antimicrobial therapy should be used when treating inflammatory lesions
Use in Special Populations
Long-term continuous therapy should be avoided in infants and children under 12 years
Overdose Effects
Acute overdosage is very unlikely, features of hypercortisolism may occur with chronic over-dosage
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C, protected from light and moisture, and out of the reach of children