Cobesol 0.05% (Cream)

10 gm tube: ৳ 45.00

Medicine Details

Category Details
Generic Clobetasol propionate
Company Pharmasia limited
Also available as
Cobesol 005 ointment

Indications

  • Psoriasis (excluding widespread plaque psoriasis)
  • Recalcitrant dermatoses
  • Lichen planus
  • Discoid lupus erythematosus
  • Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

  • Clobetasol Propionate Cream:
    • 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Ointment:
    • 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Scalp Application:
    • 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Shampoo:
    • 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Lotion:
    • 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Spray:
    • 0.5 mg (0.05% w/w)

Pharmacology

  • Very potent topical corticosteroid
  • Anti-inflammatory
  • Antipruritic
  • Vasoconstrictive
  • Inhibits late phase allergic reactions
  • Decreases mast cell density
  • Reduces cytokine production
  • Inhibits arachidonic acid metabolism

Dosage

  • Cream, Ointment:
    • Apply a thin layer twice daily to affected skin areas
    • Maximum weekly dose: 50 gm/week
  • Spray:
    • Apply once or twice daily to affected areas of the scalp
    • Total dose should not exceed 50 ml weekly
  • Shampoo:
    • Applied once a day to affected areas only
    • Total dosage should not exceed 50 g per week
  • Scalp Solution:
    • Apply once or twice daily to affected areas of the scalp
    • Total dose should not exceed 50 ml weekly
  • General:
    • Treatment with super-high potency corticosteroids should be limited to 2 consecutive weeks

Administration

  • Route of Administration: Cutaneous
  • Creams: Moist or weeping surfaces
  • Ointments: Dry, lichenified or scaly lesions

Interaction

  • Co-administration with drugs inhibiting CYP3A4 can increase systemic exposure

Contraindications

  • Rosacea, acne vulgaris and perioral dermatitis
  • Hypersensitivity to the preparation
  • Dermatoses in children under one year of age

Side Effects

  • Systemic absorption leading to hypercorticism
  • Local atrophic changes in the skin
  • Pustular form of psoriasis
  • Pigmentation changes
  • Hypertrichosis

Pregnancy & Lactation

  • Limited data on use in pregnant women
  • Caution during lactation

Precautions & Warnings

  • Avoid long-term continuous therapy, particularly in infants and children
  • Use on face may cause atrophic changes
  • Avoid eye contact
  • Hazardous in psoriasis
  • Appropriate antimicrobial therapy when treating infected lesions

Use in Special Populations

  • Adrenal suppression in children under 12 years
  • Infants are more susceptible to atrophic changes

Overdose Effects

  • Unlikely to occur acutely
  • Discontinue in case of chronic over-dosage

Therapeutic Class

  • Other Topical corticosteroids

Storage Conditions

  • Keep below 30°C
  • Protected from light and moisture
  • Keep out of reach of children

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