Cobesol 0.05% (Ointment)
10 gm tube: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Pharmasia limited |
| Also available as |
Indications
- For psoriasis (excluding widespread plaque psoriasis)
- For recalcitrant dermatoses
- For lichen planus
- For discoid lupus erythematosus
- For other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream contains 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment contains 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application contains 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo contains 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion contains 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray contains 0.5 mg (0.05% w/w)
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory properties
- Antipruritic properties
- Vasoconstrictive properties
- Inhibits late phase allergic reactions
- Decreases mast cell density
- Inhibits eosinophil activation
- Reduces cytokine production
Dosage
- Apply a thin layer of cream or ointment twice daily
- Short courses may be used to control exacerbations
- Enhance effect by occluding treatment area
- Super-high potency topical corticosteroid
- Treatment should be limited to 2 consecutive weeks
- Maximum weekly dose should not exceed 50 gm/week
Administration
- Route of administration: Cutaneous
- Creams appropriate for moist or weeping surfaces
- Ointments appropriate for dry, lichenified, or scaly lesions
Interaction
- Co-administered drugs that can inhibit CYP3A4 may increase systemic exposure
Contraindications
- Not indicated for rosacea, acne vulgaris, or perioral dermatitis
- Hypersensitivity to the preparation
- Not indicated for primarily infected skin lesions caused by fungi or bacteria
Side Effects
- Prolonged use can result in hypercorticism
- May cause local atrophic changes in the skin
- Reports of pigmentation changes and hypertrichosis
- Exacerbation of symptoms may occur
Pregnancy & Lactation
- Limited data on use in pregnant women
- Topical administration to pregnant animals can cause foetal abnormalities
- Unknown excretion in human milk
- Caution should be exercised when administered to a nursing woman
Precautions & Warnings
- Long-term continuous therapy should be avoided, particularly in infants and children
- Atrophic changes may occur on the face after prolonged treatment
- Care needed to avoid entry into the eye
- Hazardous in psoriasis for a number of reasons
Use in Special Populations
- Avoid long-term continuous therapy in infants and children under 12 years
- Children are more susceptible to developing atrophic changes
Overdose Effects
- Acute overdosage is very unlikely to occur
- Chronic over-dosage may result in hypercortisolism
Therapeutic Class
- Other Topical corticosteroids
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Do not freeze
- Keep out of the reach of children