Xerova 20 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 7: ৳ 280.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Title
- Xerova 20 mg Tablet
Categories
- Medicine
- Healthcare
- Pharmaceutical
Indications
- Indicated as an adjunct to diet to reduce elevated total cholesterol
- LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase
- Increases the number of hepatic LDL receptors for enhanced uptake and catabolism of LDL
Absorption
- Rapidly absorbed after oral administration
- Maximum plasma concentrations occur within 1 to 2 hours
- Extent of absorption increases in proportion to dose
Distribution
- Mean volume of distribution is approximately 381 liters
- 98% bound to plasma proteins
- Not expected to undergo enterohepatic recirculation
Metabolism
- Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
- Importance of metabolism by cytochrome P450 3A4
Excretion
- Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
- Mean plasma elimination half-life is approximately 14 hours
Dosage & Administration
- Adults usually take 10 mg once daily; may be increased to max. 80 mg once daily if necessary
- Children (10-18 years) initially take 10 mg once daily; increased to usual max. 20 mg once daily if necessary
Interaction
- Risk of myopathy increased with concurrent administration of certain drugs
- Plasma concentrations altered when coadministered with antacid, colestipol, digoxin, erythromycin, oral contraceptives, or warfarin
Contraindications
- Hypersensitivity to any component of this medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy & Lactation
- Atorvastatin is contraindicated during pregnancy
- Not known whether atorvastatin or its metabolites are excreted in human milk
Precautions & Warnings
- Liver function tests should be performed before initiation of treatment
- Used with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
Use in Special Populations
- Plasma concentrations are higher in healthy elderly subjects than in young adults
- No clinically significant difference in LDL-C reduction between men and women
- Renal disease has no influence on the plasma concentrations
- Hemodialysis is not expected to significantly enhance clearance
- In patients with chronic alcoholic liver disease, plasma concentrations are markedly increased
Overdose Effects
- Specific treatment is not available for atorvastatin overdose
- The patient should be treated symptomatically and supportive measures instituted
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
- Chemical Structure available
Common Questions
- What is Xerova 20 mg Tablet?
- How should I take Xerova 20 mg Tablet?
- What are the uses of Xerova 20 mg Tablet?
- What are the Side Effects of Xerova 20 mg Tablet?
- What are the instructions for storage and disposal Xerova 20 mg Tablet?
- Is Xerova 20 mg Tablet used for lowering cholesterol?
- Will taking Xerova 20 mg Tablet increase my risk of diabetes?
- For how long do I need to take Xerova 20 mg Tablet? Is it safe for long-term use?
- Does Xerova 20 mg Tablet cause weight loss?
- Can I stop taking Xerova 20 mg Tablet?
- Does Xerova 20 mg Tablet cause memory loss?
- Does Xerova 20 mg Tablet make you tired?
- Can Xerova 20 mg Tablet be prescribed to children?
- Is Xerova 20 mg Tablet a blood thinner?
- Quick Tips
Additional Information
- Xerova is generally well-tolerated
- Atorvastatin is rapidly absorbed after oral administration with maximum plasma concentrations within 1 to 2 hours
- Extent of absorption increases in proportion to Atorvastatin dose
Usability
- Can be taken with or without food
- Should be stored at room temperature away from heat and direct light
Health Considerations
- Liver function tests should be performed before initiating treatment
- Usage should be suspended during pregnancy or until it has been determined that the woman is not pregnant
Safety Information
- Should not be taken if allergic to any component of the medication
- Contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases