Dermacort 0.05% (Ointment)
10 gm tube: ৳ 52.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Ointment: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Scalp Application: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Shampoo: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Lotion: 0.5 mg (0.05% w/w)
- Clobetasol Propionate Spray: 0.5 mg (0.05% w/w)
Pharmacology
- Very potent topical corticosteroid
- Anti-inflammatory
- Antipruritic
- Vasoconstrictive
- Inhibits late phase allergic reactions
- Decreases mast cell density
- Reduces cytokine production
Dosage
- Apply a thin layer of Clobetasol Propionate Cream or Ointment twice daily
- Maximum weekly dose should not exceed 50 gm/week
- Apply Clobetasol Propionate scalp solution once or twice daily
- Therapy should be discontinued if no response is noted after one week
Administration
Route of administration: Cutaneous
Interaction
Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids
Contraindications
- Rosacea, acne vulgaris, and perioral dermatitis
- Hypersensitivity to the preparation
- Not indicated for fungal or bacterial skin infections
- Dermatoses in children under one year of age
Side Effects
- Prolonged use can result in systemic absorption
- Local atrophic changes in the skin
- Provokes pustular form of psoriasis in rare instances
- Reports of pigmentation changes and hypertrichosis
Pregnancy & Lactation
Limited data from use in pregnant women. Caution should be exercised during lactation
Precautions & Warnings
- Long-term continuous topical therapy should be avoided, especially in infants and children
- Atrophic changes may occur after prolonged treatment on the face
- Care needed to prevent entry into the eye if applied to the eye lids
- Appropriate anti-microbial therapy should be used whenever treating inflammatory lesions
Use in Special Populations
Long-term continuous topical corticosteroid therapy should be avoided in infants and children under 12 years of age
Overdose Effects
Acute overdosage is very unlikely to occur
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C, protected from light and moisture, do not freeze